Dr. Brunella Taddeo

School: Schaefer School of Engineering & Science
Department: Chemistry and Chemical Biology
Building: EAS 410
Email: btaddeo@stevens.edu

Ph.D, Microbiology and Epidemiology, “La Sapienza” University, Rome, Italy.

B.S., Biological Sciences, "La Sapienza" University, Rome, Italy.

Post-Doctoral research fellow, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA.

General Information

Dr. Brunella Taddeo obtained a B.S. in Biological Science and a Ph.D. in Microbiology & Epidemiology from “La Sapienza” University in Rome, Italy. Her post-doctoral fellowship at the Dana Farber Cancer Institute in Boston focused on the role of HIV-1 integrase in the viral replication, working under the supervision of Dr. W. Haseltine and Dr. J. Sodroski. She then expanded her interests in virology by first working on the HIV-1 and HHV-8 interactions at The Loyola University Medical center (Maywood, IL) and, after joining the Prof. B. Roizman’s team at The University of Chicago, focusing her research on the ability of Herpes Simplex Virus 1 to shut off the host cellular replication machinery. Her work led to more than 35 peer-reviewed publications. After relocating in NYC area in 2012, she pursued transferring her deep biological knowledge in educational settings by providing basic and advanced courses in Biology, Genetic, Microbiology etc. at various NYC area institutions including Mercy College, New York City College of Technology and Hostos Community College, before joining Stevens Institute of Technology as biology Lecturer in the department of Chemistry and Chemical Biology, at Charles V. Schaefer, Jr. School of Engineering & Science.

Professional Service

Adjunct Assistant Professor at CUNY (2016-2019)

Adjunct Faculty at Mercy College, Dobbs Ferry, NY (2014-2016)

Research Assistant Professor, University of Chicago, Department of Microbiology - Chicago, IL. (2005-2012)

Instructor, University of Chicago, Department of Microbiology - Chicago, IL. (2003-2004)

Research Associate, University of Chicago, Department of Molecular Genetics and Cell Biology - Chicago, IL. (1999-2002)        

Research Associate, Loyola University, Cardinal Bernardin Cancer Center, Department of Pathology - Maywood, IL. (1997-1998)       

Selected Publications
  1. Shu M., Taddeo B., and Roizman B. 2015. "Tristetraprolin recruits the Herpes Simplex virion host shutoff RNase to AU-Rich elements in stress response mRNAs to enable their cleavage", J Virol. 89: 5643-5650.
  2. Taddeo B., Zhang W., and Roizman B. 2013. "The herpes simplex virus host shutoff RNase degrades cellular and viral mRNAs made before infection but not viral mRNA made after infection.", J. Virol., 87:4516-4522.
  3. Shu M., Taddeo B., and Roizman B. 2013. "The nuclear-cytoplasmic shuttling of virion host shutoff RNase is enabled by pUL47 and an embedded nuclear export signal and defines the sites of degradation of AU-rich and stable cellular mRNAs", J. Virol. 87:13569-13578.
  4. Taddeo B., Zhang W., and Roizman B. 2010. "The role of herpes simplex virus ICP27 in the degradation of mRNA by the virion host shutoff (VHS) RNase.", J Virol., 84:10182-10190.
  5. Taddeo B., Zhang W., and Roizman B. 2009. "The virion-packaged endoribonuclease of herpes simplex virus 1 cleaves mRNA in polyribosomes", Proc Natl Acad Sci USA, 106:12139-12144.
  6. Taddeo B., Sciortino M.T., Zhang W., and Roizman B. 2007. "Interaction of herpes simplex virus RNase with VP16 and VP22 is required for the accumulation of the protein but not for accumulation of mRNA", Proc Natl Acad Sci USA, 104:12163-12168.
  • BIO 381 Cell Biology
  • BIO 484 Introduction to Molecular Genetics
  • CH 498 Chemical Research I