Xiaojun Yu

ASSOCIATE PROFESSOR, BIOMEDICAL ENGINEERING
School: Schaefer School of Engineering & Science
Department: Biomedical Engineering
Building: McLean Building
Room: 301
Phone: 201.216.5256
Fax: 201.216.8306
Email: xyu@stevens.edu
Website
Education
  • Ph.D. (Biomedical Engineering), Case Western Reserve University, Cleveland, OH, 01/2002
  • M.S. (Biomedical Engineering), Peking Union Medical College), Beijing, China, 11/92
  • B.E. (Polymeric Materials and Chemical Engineering), Tsinghua University, Beijing, China. 07/89
Research

Dr. Yu's primary research interests focus on tissue engineering, polymeric biomaterials and drug delivery. His current research activities include nano- and micro-scale functionalization of biomimic three-dimensional scaffolds for neural and musculoskeletal tissue repair and regeneration, investigation of cell and material interactions in bioreactors, development of controlled release systems for the delivery of growth factors and drugs, manipulation of microenvironment for stem cell proliferation and differentiation.

               Visit the Yu Laboratory

Experience
  • Associate Professor (09/11-present), Biomedical Engineering, Stevens Institute of Technology, Hoboken, NJ
  • Assistant Professor (06/05-08/11), Biomedical Engineering, Stevens Institute of Technology, Hoboken, NJ
  • Research Associate (04/03-06/05), Department of Orthopaedic Surgery, University of Virginia, Charlottesville, VA
  • Research PostDoc Associate (11/01-03/03), Department of Chemical Engineering, Drexel University, Philadelphia, PA
Professional Societies
The Society For Biomaterials. The Materials Research Society.
Patents & Inventions
Xiaojun Yu, Paul Lee. BIPHASIC OSTEOCHONDRAL SCAFFOLD FOR RECONSTRUCTION OF ARTICULAR CARTILAGE. US patent no. 9180223; Issued: November 10, 2015.
 
Xiaojun Yu, Wei Chang. IMPLANTABLE NERVE CONDUIT HAVING A POLYMER FIBER SPIRAL GUIDANCE CHANNEL. US patent no. 9585666; issued: March, 6, 2017.
Selected Publications
Journals
  1. Ohan S. Manoukian,Scott Stratton,Michael R. Arul, Joshua Moskow, Naseem Sardashti, Xiaojun Yu, Swetha Rudraiah, Sangamesh G. Kumbar. (2018). "Polymeric ionically conductive composite matrices and electrical stimulation strategies for nerve regeneration: In vitro characterization", J Biomed Mater Res Part B. 9999:9999: 1-14.
  2. Manoukian O.S., Aravamudhan A., Lee P., Arul M.R., Yu X., Rudraiah S., Kumbar S.G.. (2018). "Spiral Layer-by-Layer Micro-Nanostructured Scaffolds for Bone Tissue Engineering", ACS Biomaterials Science and Engineering. 4 (6), 2181-2192.
  3. Chang W., Shah M.B., Lee P., Yu X.. (2018). "Tissue-engineered spiral nerve guidance conduit for peripheral nerve regeneration", Acta Biomaterialia. 73 302-311.
  4. R. Chung, D. M. Kalyon, X. Yu, A. Valdevit. (2018). "Segmental bone replacement via patient specific, threeâ€dimensional printed bioresorbable graft substitutes and their use as templates for the culture of mesenchymal stem cells under mechanical stimulation at various frequencies", Biotechnology and Bioengineering. doi.org/10.1002/bit.26780.
  5. Zhou, G., Chang, W. Yu. X. (2018). "Nanofibrous Nerve Conduits with Pre-seeded Bone Marrow Stromal Cells and Cultured by Bioreactor for Enhancing Peripheral Nerve Regeneration", Regen. Eng. Transl. Med.. doi.org/10.1007/s40883-018-0057-z.
  6. Chang TL, Yu X, Liang JF. (2018). "Polydopamine-enabled surface coating with nano-metals", Surface & Coatings Technology. 337 387-395.
  7. Flores D, Yu X. (2017). "Innovative Tissue-Engineered and Synthetic Vascular Graft Models for the Treatment of PAD in Small-Diameter Arteries", Regen. Eng. Transl. Med. 3 (4), 215-223.
  8. Lee P., Manoukian O.S., Zhou G., Wang Y., Chang W., Yu X., Kumbar S.G.. (2016). "Osteochondral scaffold combined with aligned nanofibrous scaffolds for cartilage regeneration", RSC Advances. 76 72246-72255.
  9. Shelke N.B., Lee P., Anderson M., Mistry M., Nagarale R.K., Ma X.M., Yu X., Kumbar S.G. (2016). "Neural Tissue Engineering: Nanofiber-Hydrogel Based Composite Scaffolds", Polym. Adv. Technol. 27 42-51.
  10. Anderson M., Shelke N.B., Manoukian O.S., Yu X., McCullough L.D, Kumbar S.G.. (2015). "Peripheral Nerve Regeneration Strategies: Electrically Stimulating Polymer Based Nerve Growth Conduits", Critical Reviews in Biomedical Engineering Journal.
  11. Lee P., Tran K., Chang W., Fang Y.-L., Zhou G., Junka R., Shelke N.B., Yu X., Kumbar S.G.. (2015). "Bioactive polymeric scaffolds for osteochondral tissue engineering: In vitro evaluation of the effect of culture media on bone marrow stromal cells", Polymers for Advanced Technologies. 26 (12), 1476-1485.
  12. Radoslaw Junka and Xiaojun Yu. (2015). "Novel Acellular Scaffold Made from Decellularized Schwann Cell Sheets for Peripheral Nerve Regeneration", Regen. Eng. Transl. Med. . doi:10.1007/s40883-015-0003-2.
  13. Paul Lee, Katelyn Tran, Gan Zhou, Asheesh Bedi, Namdev B. Shelke, Xiaojun Yu and Sangamesh G. Kumbar. (2015). "Guided Differentiation of Bone Marrow Stromal Cells on Co-Cultured Cartilage and Bone Scaffolds", Soft Matter. 11 (38), 7648-55.
  14. Cheng, Y., Nada, A.A, Valmikinathan, C.M., Lee, P., Liang. D., Yu, X., and Kumbar, S.G. (2014). "In-Situ Gelling Polysaccharide Based Hydrogel for Cell and Drug Delivery in Tissue Engineering", J. Appl. Polym. Sci. 131 29934.
  15. Pavlukhina S., Zhuk I., Mentbayeva A., Rautenberg E., Chang W., Yu X., Van De Belt-Gritter B., Busscher H.J., Van Der Mei H.C., Sukhishvili S.A. (2014). "Small-molecule-hosting nanocomposite films with multiple bacteria-triggered responses", NPG Asia Materials. 6 (8), e121.
  16. Munish Shah, Wei Chang, and Xiaojun Yu. (2014). "Evaluating nerve guidance conduits for peripheral nerve injuries: a novel normalization method", Neural Regeneration Research. 9 (22), 1959-1960.
  17. Zhang X, Chang W, Lee P, Wang Y, Yang M, Li J, Kumbar SG, Yu X. (2014). "Polymer-ceramic spiral structured scaffolds for bone tissue engineering: effect of hydroxyapatite composition on human fetal osteoblasts", PLoS One. 9 (1), e85871.
  18. Lee P, Tran K, Chang W, Shelke NB, Kumbar SG, and Yu X. (2014). "Influence of Chondroitin Sulfate and Hyaluronic Acid Presence in Nanofibers and its Alignment on the Bone Marrow Stromal Cells: Cartilage Regeneration", Journal of Biomedical Nanotechnology. 10 1-11.
  19. Cheng Y, Ramos D, Lee P, Liang D, Yu X, and Sangamesh G. Kumbar. (2014). "Collagen Functionalized Bioactive Nanofiber Matrices for Osteogenic Differentiation of Mesenchymal Stem Cells: Bone Tissue Engineering", J. Biomed. Nanotechnol. 10 (2), 287-298.
  20. Chang W, DeVince J, Green G, Johns M, Shah M, Meng Y and Yu X. (2013). "The development of a novel normalization method for comparing nerve regeneration effectiveness among different graft types", Journal of Peripheral Nervous System. 18 (4), 297-305.
  21. Evensen N, Li J, Yang J, Yu X, Sampson NS, Zucker S, Cao J. (2013). "Development of A High-throughput Three-dimensional Invasion Assay for Anti-cancer Drug Discovery", PLoS One. 8 (12), e82811.
  22. Junka R, Valmikinathan CM, Kalyon DM, and Yu X. (2013). "Laminin Functionalized Biomimetic Nanofibers for Nerve Tissue Engineering", J. Biomater. Tissue Eng. . 3 494-502.
  23. Aravamudhan A, Ramos DM, Nip J, Subramaniam A, James R, Harmon MD, Yu X and Kumbar SG. (2013). "Osteoinductive Small Molecules: Growth Factor Alternatives for Bone Tissue Engineering", Current Pharmaceutical Design. 19 3420-3428.
  24. Wang Q., Yu X., Libera M.. (2013). "Reducing Bacterial Colonization of 3-D Nanofiber Cell Scaffolds by Hierarchical Assembly of Microgels and an Antimicrobial Peptide", Advanced Healthcare Materials. 5 687-691.
  25. Pesirikan N, Chang W, Zhang X, Xu J, and Yu X.. (2013). "Characterization of Schwann Cells in Self Assembled Sheets from Thermo-responsive Substrates", Tissue Engineering Part A, . 9 (13-14), 1601-9.
  26. Aja Aravamudhan, Daisy M. Ramos, Jonathan Nip, Matthew D. Harmon, Roshan James, Meng Deng, Cato T. Laurencin, Xiaojun Yu, and Sangamesh G. Kumbar.. (2013). Cellulose and Collagen Derived Micro‐Nano Structured Scaffolds for Bone Tissue Engineering, J. Biomed. Nanotechnol.. 9 719-731.
  27. Junping Wang, Ceren Örnek‐Ballanco, Jiahua Xu, Weiguo Yang, and Xiaojun Yu. (2013). "Preparation and characterization of vinculin‐targeted polymer–lipid nanoparticle as intracellular delivery vehicle", Int J Nanomedicine, 8 39-46.
  28. Asli Ergun, Xiaojun Yu, Antonio Valdevit, Arthur Ritter and Dilhan M. Kalyon,. (2012). "Radially and axially‐graded multizonal scaffolds targeting critical‐sized bone defects from polycaprolactone/hydroxyapatite/tricalcium phosphate", Tissue Engineering A,, 18 (23-24), 2426‐2436.
  29. Pavlukhina SV, Kaplan JB, Xu L, Chang W, Yu X, Madhyastha S, Yakandawala N, Mentbayeva A, Khan B, Sukhishvili SA.. (2012). Noneluting enzymatic antibiofilm coatings., ACS Appl Mater Interfaces.. 4 (9), 4708-16.
  30. Valmikinathan CM, Chang W, Xu J, and Yu X.. (2012). Self assembled temperature responsive surfaces for generation of cell patches for bone tissue engineering, Biofabrication. 4 (3), 035006.
  31. Ergun A, Yu X, Valdevit A, Ritter A, Kalyon DM.. (2011). In vitro analysis and mechanical properties of twin screw extruded single‐layered and coextruded multilayered poly(caprolactone) scaffolds seeded with human fetal osteoblasts for bone tissue engineering, J Biomed Mater Res A.. 99 (3), 354‐66.
  32. Wang JP, Zhu YZ, Bawa HK, Ng G, Wu Y, Libera M, van der Mei, HC, Busscher HJ, and Yu X.. (2011). Oxygen‐Generating Nanofiber Cell Scaffolds with Antimicrobial Properties, Applied materials and Interfaces. 3 (1), 67 ‐73.
  33. Wu Y, Zitelli JP, TenHuisen KA, Yu X, and Libera MR.. (2011). Differential response of Staphylococci and osteoblasts to varying titanium surface roughness, Biomaterials. 32 (4), 951‐60.
  34. Wang JP, Shah A, and Yu. X.,. (2011). The influence of fiber thickness, wall thickness and gap distance on the spiral nanofibrous scaffolds for bone tissue engineering, Materials Science and Engineering C. 31 50-56.
  35. Valmikinathan CM, Hoffman J, and Yu X.. (2011). Impact of scaffold micro and macro architecture on Schwann cell proliferation under dynamic conditions in a rotating wall vessel bioreactor”,, Materials Science and Engineering C. 31 22-29.
  36. Ozkan S, Kalyon DM, and Yu X.,. (2010). Functionally graded beta‐TCP/PCL nanocomposite scaffolds: In vitro evaluation with human fetal osteoblast cells for bone tissue engineering, J Biomed Mater Res A.. 92 (3), 1007‐18.
  37. Wang JP, Valmikinathan CM, Liu W, Laurencin CT, and Yu X,. (2010). Spiral‐Structured, Nanofibrous, 3D Scaffolds for Bone Tissue Engineering, J Biomed Mater Res A.. 93 (2), 753‐762.
  38. Wang JP, and Yu X.. (2010). Preparation, characterization and in vitro analysis of novel structured nanofibrous scaffolds for bone tissue engineering, Acta Biomaterialia. 6 3004-3012.
  39. Ozkan S, Kalyon DM, Yu X, McKelvey C, and Lowinger M. (2009). Multifunctional polycaprolactone (PCL) scaffolds for controlled release and tissue engineering applications: In vitro evaluation of released protein secondary structure stability, release profile and biocompatibility, Biomaterials. 30 4336-4347.
  40. Wang JP, Valmikinathan CM and Yu X,. (2009). Nanostructures for Bypassing Blood Brain Barrier, Current Bioactive Compounds. 5 (3), 195-205.
  41. Degirmenbasi N, Ozkan S, Kalyon DM and Yu, X.. (2009). Surface patterning of poly (L‐lactide) upon melt processing: in vitro culturing of fibroblasts and osteoblasts on surfaces ranging from highly crystalline with spherulitic protrusions to amorphous with nanoscale indentations., Journal of Biomedical Materials Research Part A.. 88 (1), 94‐104.
  42. Valmikinathan CM, Defroda S, and Yu X.,. (2009). Polycaprolactone and bovine serum albumin based nanofibers for controlled release of nerve growth factor, Biomacromolecules. 10 (5), 1084‐9.
  43. Chandra M. Valmikinathan, Junping Wang, Sergio Smiriglio, Neha G. Golwala, and Xiaojun Yu.. (2009). "Magnetically induced protein gradients on electrospun nanofibers. ", Combinatorial Chemistry & High Throughput Screening. 12 656-663.
  44. Nebahat Degirmenbasi, Seher Ozkan, Dilhan M. Kalyon and Yu, X.. (2009). "Surface patterning of poly (L-lactide) upon melt processing: in vitro culturing of fibroblasts and osteoblasts on surfaces ranging from highly crystalline with spherulitic protrusions to amorphous with nanoscale indentations. ", Journal of Biomedical Materials Research PartA. . 88 (1), 94-104.
  45. Chandra M Valmikinathan, Jingjing Tian, Junping Wang, and Yu X. (2008). "Novel nanofibrous spiral scaffolds for neural tissue engineering.", Journal of Neural Engineering. 5 422-432.
  46. Laurencin CT, Khan Y, Kofron M, El-Amin S, Botchwey E, Yu X, Cooper JA Jr. (2006). "The ABJS Nicolas Andry Award: Tissue engineering of bone and ligament: a 15-year perspective (review) ", Clin Orthop Relat Res. , 447 221-236.
  47. X. Yu, E.A. Botchwey, E.M. Levine, S.R. Pollack and C.T. Laurencin.. (2004). "Bioreactor-based bone tissue engineering: the influence of dynamic flow on osteoblast phenotype expression and matrix mineralization", Proc Natl Acad Sci USA. 101 (31), 11203-8.
  48. X. Yu and R.V. Bellamkonda.. (2003). "Tissue-engineered scaffolds are effective alternatives to autografts for bridging peripheral nerve gaps. ", Tissue Engineering. 9 (3), 421-430.
  49. X. Yu and R.V. Bellamkonda. (2001). "Dorsal root ganglia neurite extension across mechanical and charged interfaces.", Journal of Neuroscience Research, 66 303-310.
  50. A.P. Balgude, X. Yu, A. Szymanski and R.V. Bellamkonda. (2001). "Agarose gel stiffness determines rate of DRG neurite extension in 3D cultures.", Biomaterials. 22 (10), 1077-1084.
  51. N.J. Meilander, X. Yu, N.P. Ziats and R.V. Bellamkonda. (2001). "Lipid-based microtubular drug delivery vehicles", J Control Release. 71 (1), 141-152.
  52. Y. Zhong, X. Yu, R. Gilbert, R.V. Bellamkonda. (2001). "Stabilizing electrode-host interfaces: a tissue engineering approach.", Journal of Rehabilitation Research and Development, 38 (6), 627-632.
  53. G.P. Dillon, X. Yu and R.V. Bellamkonda. (2000). "The polarity and magnitude of ambient charge influences three-dimensional neurite extension from DRGs", Journal of Biomedical Materials Research, 51 (3), 510-519.
  54. D.A. Eavarone, X. Yu and R.V. Bellamkonda. (2000). "Receptor-mediated targeting of C6 glioma by transferrin-coupled liposomes.", Journal of Biomedical Materials Research, 51 (1), 10-14.
  55. X. Yu, G.P. Dillon and R.V. Bellamkonda. (1999). "A laminin and nerve growth factor laden 3D matrix for enhanced neurite extension.", Tissue Engineering. 5 (4), 291-304.
  56. G.P. Dillon, X. Yu, A. Sridharran, J.P. Ranieri and R.V. Bellamkonda. (1998). "The influence of physical structure and charge on neurite extension in a 3D hydrogel scaffold.", Journal of Biomaterials Science: Polymer Edition 9, 1015-1114.
Courses
  • BME 602 Principles of Tissue Engineering
  • BME 685 Nanobiotechnology