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Introduction to mammalian physiology from an engineering point of view. The quantitative aspects of normal cellular and organ functions and the regulatory processes required to maintain organ viability and homeostasis. Laboratory exercises using exercise physiology as an integration of function at the cellular, organ and systems level will be conducted at the same time. Measurements of heart activity (EKG), cardiac output (partial CO2 rebreathing), blood pressure, oxygen consumption, carbon dioxide production, muscle strength (EMG), fluid shifts and respiratory function in response to exercise stress will be measured and analyzed from an engineering point of view.
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This course will provide students with a practical approach to current computational and experimental methods used in the field of biomechanics. The goal of the course will be to bridge the gap between the theoretical computations and the practical application of experimental techniques. Topics covered will include cartilage and muscle mechanics as well as the response of bone tissue to loading. The analysis of implants will also be covered. The course will conclude with analysis of human motion. Experiments will be associated with various topics to demonstrate practical applications of the theoretical concepts introduced. Students will be required to use statistical analysis software. Prerequisites: BME 506 Biomechanics, BME 505 Biomaterials, knowledge of, or courses in Differential Equations, Multivariable Calculus and Statistics.
Prerequisites:
BME 505 Biomaterials
(2-3-3)(Lec-Lab-Credit Hours)
Intended as an introduction to materials science for biomedical engineers, this course first reviews the materials properties relevant to the their application to the human body. It goes on to discuss proteins, cells, tissues, and their reactions and interactions with foreign materials, as well as the degradation of these materials in the human body. The course then treats various implants, burn dressings, drug delivery systems, biosensors, artificial organs, and elements of tissue engineering. Laboratory exercises accompany the major topics discussed in class and are conducted at the same time.
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Biomechanics
(3-0-3)(Lec-Lab-Credit Hours)
This course reviews basic engineering principles governing materials and structures such as mechanics, rigid body dynamics, fluid mechanics and solid mechanics and applies these to the study of biological systems such as ligaments, tendons, bone, muscles, joints, etc. The influence of material properties on the structure and function of organisms provides an appreciation for the mechanical complexity of biological systems. Methods for both rigid body and deformational mechanics are developed in the context of bone, muscle, and connective tissue. Multiple applications of Newton's Laws of mechanical are made to human motion.
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The Sensory Systems I course will focus on speech, audition, and vision systems. Students will begin with a review of system principles including sampling, filtering, analog to digital conversion (ADC), spectral (Fourier) analysis and transfer functions. The second topic will cover the audio spectrum and properties of sound as they relate to both speech and hearing. The course will then cover basic anatomy and physiology of the larynx, ear, and eye. Students will participate in two types of Labs for each of the three topics. Sensory Labs are designed to enhance the student’s knowledge of sound production, auditory response and image processing. Reverse Engineering (RE) Labs utilizing existing speech, hearing, and vision enhancement products will be conducted as well.
Prerequisites:
BME 306 Introduction to Biomedical Engineering
(3-0-3)(Lec-Lab-Credit Hours)
Overview of the biomedical engineering field with applications relevant to the healthcare industry such as medical instrumentation and devices. Introduction to the nervous system, propagation of the action potential, muscle contraction and introduction to the cardiovascular system. Discussion of ethical issues in biomedicine. Prerequisite: Sophomore Standing.
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Engineering Physiology
(3-3-4)(Lec-Lab-Credit Hours)
Introduction to mammalian physiology from an engineering point of view. The quantitative aspects of normal cellular and organ functions and the regulatory processes required maintaining organ viability and homeostasis. Laboratory exercises using exercise physiology as an integration of function at the cellular, organ and systems level will be conducted at the same time. Measurements of heart activity (EKG), cardiac output (partial CO2 rebreathing), blood pressure, oxygen consumption, carbon dioxide production, muscle strength (EMG), fluid shifts and respiratory function in response to exercise stress will be measured and analyzed from an engineering point of view.
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Circuits and Systems
(2-3-3)(Lec-Lab-Credit Hours)
Ideal circuit elements; Kirchoff laws and nodal analysis; source transformations; Thevenin/Norton theorems; operational amplifiers; response of RL, RC and RLC circuits; sinusoidal sources and steady state analysis; analysis in frequenct domain; average and RMS power; linear and ideal transformers; linear models for transistors and diodes; analysis in the s-domain; Laplace transforms; transfer functions.
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| | (3-0-3) (Lec-Lab-Credit Hours)
This course introduces biomedical engineering principles, techniques, design &
application of medical instrumentation. This course deals with the sensors,
electrodes and analog integrated circuits to process physiological signals in
a way that it can be used further for various diagnostic, therapeutic and
surgical applications. It also introduces matrix laboratory and LabVIEW
software to measure, record and monitor physiological signals. The course
includes a bioinstrumentation lab where students gain hands on experience with
the use of sensors, electrodes, filters, microcontrollers and circuits to
acquire, modify and display various physiological signals. Students are
graded based on the performance in homework assignments, lab assignments and midterm & final exams.
Prerequisites:
BME 423 Senior Design I
(0-8-3)(Lec-Lab-Credit Hours)
Senior design courses. Senior design provides, over the course of two semesters, a collaborative design experience with a significant biomedical problem related to human health. The project will often originate with an industrial sponsor or a medical practitioner at a nearby medical facility and will contain a clear implementation objective (i.e. for a medical device). It is a capstone experience that draws extensively on the student’s engineering and scientific background and requires independent judgments and actions. The project generally involves a determination of the medical need, a detailed economic analysis of the market potential, physiological considerations, biocompatibility issues, ease of patient use, an engineering analysis of the design, manufacturing considerations and experimentation and/or prototype construction of the device. The faculty advisor, industrial sponsor or biomedical practitioner works closely with the group to insure that the project meets its goals in a timely way. Leadership and entrepreneurship are nourished throughout all phases of the project. The project goals are met in a stepwise fashion, with each milestone forming a part of a final report with a common structure. Oral and written progress reports are presented to a panel of faculty at specified intervals and at the end of each semester.
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A successful approach to product development and design in the field of medical technologies requires a highly interdisciplinary approach. This course reviews the regulations, protocols, and guidelines which must be met in each discipline, and describes how these issues are inter-related and how the affect design and product development. Marketing, Regulatory, IP and Clinical aspects are all considered in the technical aspects of design.
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One of the distinguishing features of biomedical engineers is the ability to make and interpret measurements on living systems. One of the major objectives of advanced laboratory training is to provide experience in selecting appropriate measurement and analysis tools that will advance hypothesis driven and translational research and development. This laboratory serves these dual purposes. Students are introduced to techniques for measurements at the cellular, organ and systems levels. Students will then use these techniques to: a) formulate hypotheses, design experiments using the tools provided, make appropriate measurements, analyze the data an determine if the data do or do not support their hypotheses; b) make measurements that facilitate the design and manufacture of devices in terms of materials properties, fatigue and failure modes. Each student will keep a laboratory notebook.
Prerequisites:
BME 503 Physiological Systems
(3-0-3)(Lec-Lab-Credit Hours)
Introduction to mammalian physiology from an engineering point of view. The quantitative aspects of normal cellular and organ functions and the regulatory processes required to maintain organ viability and homeostasis. Laboratory exercises using exercise physiology as an integration of function at the cellular, organ and systems level will be conducted at the same time. Measurements of heart activity (EKG), cardiac output (partial CO2 rebreathing), blood pressure, oxygen consumption, carbon dioxide production, muscle strength (EMG), fluid shifts and respiratory function in response to exercise stress will be measured and analyzed from an engineering point of view.
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Biomaterials
(2-3-3)(Lec-Lab-Credit Hours)
Intended as an introduction to materials science for biomedical engineers, this course first reviews the materials properties relevant to the their application to the human body. It goes on to discuss proteins, cells, tissues, and their reactions and interactions with foreign materials, as well as the degradation of these materials in the human body. The course then treats various implants, burn dressings, drug delivery systems, biosensors, artificial organs, and elements of tissue engineering. Laboratory exercises accompany the major topics discussed in class and are conducted at the same time.
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This course is an introduction to the field of Tissue Engineering. It is rapidly emerging as a therapeutic approach to treating damaged or diseased tissues in the biotechnology industry. In essence, new and functional living tissue can be fabricated using living cells combined with a scaffolding material to guide tissue development. Such scaffolds can be synthetic, natural, or a combination of both. This course will cover the advances in the field of cell biology, molecular biology, material science and their relationship towards developing novel 'tissue engineered' materials.
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The engineering applications of biological transport phenomena are important considerations in basic research related to molecules, organelles, cell and organ function; the design and operation of devices such as filtration units for kidney dialysis, high density cell culture and biosensors; and applications including drug and gene delivery, biological signal transduction and tissue engineering. This course develops the fundamental principles of transport processes, the mathematical expression of these principles and the solution of transport equations, along with characterization of composition, and function of living systems to which they are applied.
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| | (3-0-3) (Lec-Lab-Credit Hours)
Upon completion of this course, students will be able to demonstrate an understanding of the major classes of engineering materials, their principle properties and design requirements that serve as both the basis for materials selection as well as for the ongoing development of new materials. This course is substantially differentiated from introductory materials courses by its very specific focus on material whose use puts them in direct contact with physiological systems. Thus the course begins with brief sections on inflammatory response, thrombosis, infection and device failure. It then concentrates on developing the fundamental material science and engineering concepts underlying the structure-property relationships in both synthetic and natural polymers, metals and alloys, and ceramics relevant to in vivo medial-device technology.
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This course extends concepts present in tissue engineering, biotransport and biomaterial to develop design principles for generating tissue and organs in-vitro. The processes which cells integrate proteins and extracellular matrix to form functioning organ systems are developed. The principles of bioreactor design are sued to analyze and design in-vitro systems for growing functioning tissue and organs for use as prostheses. Principles of Scale-up to organs of different size are discussed. Design issues and limitations for extension of these principles to multi-organ systems are illustrated.
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Pathophysiology describes changes in physiology resulting in disease or injury. A solid understanding of normal physiology is necessary before attempting the study of abnormal situations. The course emphasizes the "mechanistic" approach to pathophysiology, i.e., A-B-C, rather that the symptom-diagnosis-treatment approach. Multiple examples, case studies and procedural videos are presented with a discussion of what they do well and where improvements can be made.
Prerequisites:
CH 583 Physiology
(3-0-3)(Lec-Lab-Credit Hours)
Fundamentals of control processes governing physiological systems analyzed at the cellular and molecular level. Biological signal transduction and negative feedback control of metabolic processes. Examples from sensory, nervous, cardiovascular, and endocrine systems. Deviations that give rise to abnormal states; their detection, and the theory behind the imaging and diagnostic techniques such as MRI, PET, SPECT; and the design and development of therapeutic drugs. The principles, uses, and applications of biomaterials and tissue engineering techniques; and problems associated with biocompatibility. Students (or groups of students) are expected to write and present a term project.
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| | | (3-0-3) (Lec-Lab-Credit Hours)
This course will provide a comprehensive introduction to the rapidly developing field of nanomedicine, and discuss the application of nanoscience and nanotechnology in medicine such as in diagnosis, imaging and therapy, surgery and drug delivery.
Prerequisites:
NANO 600
(3-0-3)(Lec-Lab-Credit Hours)
This course deals with the fundamentals and applications of nanoscience and nanotechnology. Size-dependent phenomena, ways and means of designing and synthesizing nanostructures, and cutting-edging applications will be presented in an integrated and interdisciplinary manner.
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| | (3-0-3) (Lec-Lab-Credit Hours)
This course describes the application of nano- and micro-fabrication methods to build tools for exploring the mysteries of biological systems. It is a graduate-level course that will cover the basics of biology and the principles and practice of nano- and micro-fabrication techniques with a focus on applications in biomedical and biological research.
Prerequisites:
NANO 600
(3-0-3)(Lec-Lab-Credit Hours)
This course deals with the fundamentals and applications of nanoscience and nanotechnology. Size-dependent phenomena, ways and means of designing and synthesizing nanostructures, and cutting-edging applications will be presented in an integrated and interdisciplinary manner.
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| | (3-0-3) (Lec-Lab-Credit Hours)
This advanced course coves the mechanism and biological role of signal transduction in mammalian cells. Topics included are exracellular regulatory signals, intercellular signal transduction pathways, role of tissue context in the function of cellular regulation, and example of biological processes controlled by specific cellular signal transduction pathways.
Prerequisites:
CH 381
(3-3-4)(Lec-Lab-Credit Hours)
The structure and function of the cell and its subcellular organelles is studied. Biological macromolecules, enzymes, biomembranes, biological transport, bioenergetics, DNA replication, protein synthesis and secretion, motility, and cancer are covered. Cell biology experiments and interactive computer simulation exercises are conducted in the laboratory.
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(3-3-4)(Lec-Lab-Credit Hours)
Introduction to the study of molecular basis of inheritance. Starts with classical Mendelian genetics and proceeds to the study and function of DNA, gene expression and regulation in prokaryotes and eukaryotes, genome dynamics and the role of genes in development, and cancer. All topics include discussions of current research advances. Accompanied by laboratory section that explores the lecture topics in standard wet laboratory experiments and in computer simulations.
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This course deals with the principles of light interactions with biological- and biomedical-relevant systems. The enabling aspects of nanotechnology for advanced biosensing, medical diagnosis, and therapeutically treatment will be discussed.
Prerequisites:
NANO 600
(3-0-3)(Lec-Lab-Credit Hours)
This course deals with the fundamentals and applications of nanoscience and nanotechnology. Size-dependent phenomena, ways and means of designing and synthesizing nanostructures, and cutting-edging applications will be presented in an integrated and interdisciplinary manner.
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| | (3-0-3) (Lec-Lab-Credit Hours)
Lectures by department faculty, guest speakers and doctoral students on recent research.
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Selected topics of current interest in the field of biomedical engineering will be treated from an advanced point of view.
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| | (3-0-3) (Lec-Lab-Credit Hours)
International graduate students may arrange an educationally relevant
internship or paying position off campus and receive Curricular Practical
Training (CPT) credit via this course. Students must maintain their full time
status while receiving CPT. Prior approval of the program director is
required for enrollment. To justify enrollment, the student must have a
concrete commitment from a specific employer for a specific project, and must
provide to the program director for his/her approval a description of the
project plus a statement from the employer that he/she intends to employ the
student. This information must be provided to the program director with
sufficient advance notice so that the program director has time to review the
materials and determine if the project is appropriate. The project must be
educationally relevant; i.e., it must help the student develop skills
consistent with the goals of the educational program. During the semester,
the student must submit written progress reports. At the end of the semester,
the student must submit for grading a written report that describes his/her
activities during that semester, even if the activity remains ongoing. The
student must also present his/her activities in an accompanying oral
presentation that is also graded.
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| | (0-0-3) (Lec-Lab-Credit Hours)
One to three credits. Limit of three credits for the degree of Master of Engineering (Biomedical).
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| | (0-0-9) (Lec-Lab-Credit Hours)
For the degree of Master of Engineering (Biomedical). Nine credits with departmental approval
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| | (0-0-6) (Lec-Lab-Credit Hours)
Design project for the degree of Master of Engineering (Biomedical). Hours to be arranged. Six credits, with departmental approval.
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| | (0-0-3) (Lec-Lab-Credit Hours)
Original research leading to the doctoral dissertation. Hours and credits to be arranged.
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Description of simple physical models which account for electrical conductivity and thermal properties of solids. Basic crystal lattice structures, X-ray diffraction and dispersion curves for phonons and electrons in reciprocal space. Energy bands, Fermi surfaces, metals, insulators, semiconductors, superconductivity and ferromagnetism. Fall semester. Typical text: Kittel, Introduction to Solid State Physics.
Prerequisites:
PEP 242 Modern Physics
(3-0-3)(Lec-Lab-Credit Hours)
Simple harmonic motion, oscillations and pendulums; Fourier analysis; wave properties; wave-particle dualism; the Schrödinger equation and its interpretation; wave functions; the Heisenberg uncertainty principle; quantum mechanical tunneling and application; quantum mechanics of a particle in a "box," the hydrogen atom; electronic spin; properties of many electron atoms; atomic spectra; principles of lasers and applications; electrons in solids; conductors and semiconductors; the n-p junction and the transistor; properties of atomic nuclei; radioactivity; fusion and fission. Spring Semester.
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Electromagnetism
(3-0-3)(Lec-Lab-Credit Hours)
Electrostatics; Coulomb-Gauss law; Poisson-Laplace equations; boundary value problems; image techniques;dielectric media; magnetostatics; multipole expansion; electromagnetic energy; electromagnetic induction; Maxwell’s equations; electromagnetic waves, radiation, waves in bounded regions, wave equations and retarded solutions; simple dipole antenna radiation theory; transformation law of electromagnetic fields. Spring semester. Typical text: Reitz, Milford and Christy, Foundation of Electromagnetic Theory.
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Lectures, demonstrations and laboratory experiments, selected from among the following topics, depending on student interest: vacuum technology; thin-film preparation; scanning electron microscopy; infrared spectroscopy, ellipsometry: electron spectroscopies-Auger,
photoelectron, LEED; ion spectroscopies SIMS, IBS, field emission; surface
properties-area, roughness, and surface tension.
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| | (3-0-3) (Lec-Lab-Credit Hours)
This course is an introduction to quantum mechanics for students in physics and engineering. Techniques discussed include solutions of the Schrodinger equation in one and three dimensions, and operator and matrix methods. Applications include infinite and finite quantum wells, barrier penetration and scattering in one dimension, the harmonic oscillator, angular momentum, central force problems, including the hydrogen atom, and spin. Fall semester. Typical text: Quantum Physics by Gasiorowicz
Prerequisites:
MA 221 Differential Equations
(4-0-4)(Lec-Lab-Credit Hours)
Ordinary differential equations of first and second order, homogeneous and non-homogeneous equations; improper integrals, Laplace transforms; review of infinite series, series solutions of ordinary differential equations near an ordinary point; boundary-value problems; orthogonal functions; Fourier series; separation of variables for partial differential equations.
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Modern Physics
(3-0-3)(Lec-Lab-Credit Hours)
Simple harmonic motion, oscillations and pendulums; Fourier analysis; wave properties; wave-particle dualism; the Schrödinger equation and its interpretation; wave functions; the Heisenberg uncertainty principle; quantum mechanical tunneling and application; quantum mechanics of a particle in a "box," the hydrogen atom; electronic spin; properties of many electron atoms; atomic spectra; principles of lasers and applications; electrons in solids; conductors and semiconductors; the n-p junction and the transistor; properties of atomic nuclei; radioactivity; fusion and fission. Spring Semester.
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| | (3-0-3) (Lec-Lab-Credit Hours)
This course is meant as the first in a two-course sequence on non-relativistic quantum mechanics for physics graduate students, with an emphasis on applications to atomic, molecular, and solid state physics. Undergraduate students may take this course as a Technical Elective. Topics covered include: review of Schrödinger wave mechanics; operator algebra, theory of representation, and matrix mechanics; symmetries in quantum mechanics; spin and formal theory of angular momentum, including addition of angular momentum; and approximation methods for stationary problems, including time independent perturbation theory, WKB approximation, and variational methods. Typical text: Quantum Mechanics by E. Merzbacher.
Prerequisites:
PEP 532 PEP 538 Introduction to Mechanics
(3-0-3)(Lec-Lab-Credit Hours)
Particle motion in one dimension. Simple harmonic oscillators. Motion in two and three dimensions, kinematics, work and energy, conservative forces, central forces, and scattering. Systems of particles, linear and angular momentum theorems, collisions, linear spring systems, and normal modes. Lagrange’s equations and applications to simple systems. Introduction to moment of inertia tensor and to Hamilton’s equations.
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Quantum Mechanics and Engineering Applications
(3-0-3)(Lec-Lab-Credit Hours)
This course is meant to serve as an introduction to formal quantum mechanics as well as to apply the basic formalism to several generic and important applications.
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Most processes in petroleum and chemical industries utilize catalytic reactions. Moreover, many emerging technologies in the energy sector and in green chemistry for sustainability rely on catalysis. This course provides the fundamentals of synthesis, characterization and testing of catalytic materials with an emphasis on metal and metal oxide nanoparticles, the most widely used class of catalysts. Methodologies for development of molecular-level reaction mechanisms, material structure-activity relations and kinetic models are described. The course is essential for anyone planning a career in the chemical industry. It is recommended for all professionals working with nanoparticles and also with diverse applications where the solid-gas interface is important.
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| | (3-0-3) (Lec-Lab-Credit Hours)
Principles of environmental reactions with emphasis on aquatic chemistry; reaction and phase equilibria; acid-base and carbonate systems; oxidation-reduction; colloids; organic contaminants classes, sources, and fates; groundwater chemistry; and atmospheric chemistry.
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| | (3-0-3) (Lec-Lab-Credit Hours)
A study of the chemical and physical operation involved in treatment of potable water, industrial process water, and wastewater effluent; topics include chemical precipitation, coagulation, flocculation, sedimentation, filtration, disinfection, ion exchange, oxidation, adsorption, flotation, and membrane processes. A physical-chemical treatment plant design project is an integral part of the course. The approach of unit operations and unit processes is stressed.
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| | (3-0-3) (Lec-Lab-Credit Hours)
Deals with aspects of the technology of processing procedures involved in the fabrication of microelectronic devices and microelectromechanical systems (MEMS). Students will become familiar with various fabrication techniques used for discrete devices as well as large-scale integrated thin-film circuits. Students will also learn that MEMS are sensors and actuators that are designed using different areas of engineering disciplines and they are constructed using a microlithographically-based manufacturing process in conjunction with both semiconductor and micromachining microfabrication technologies
Prerequisites:
PEP 507 Introduction to Microelectronics and Photonics
(3-0-3)(Lec-Lab-Credit Hours)
An overview of Microelectronics and Photonics Science and Technology. It provides the student who wishes to specialize in the application, physics or fabrication with the necessary knowledge of how the different aspects are interrelated. It is taught in three modules: design and applications, taught by EE faculty; operation of electronic and photonic devices, taught by Physics faculty; fabrication and reliability, taught by the
Materials faculty.
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| | (3-0-3) (Lec-Lab-Credit Hours)
This course deals with the fundamentals and applications of nanoscience and nanotechnology. Size-dependent phenomena, ways and means of designing and synthesizing nanostructures, and cutting-edging applications will be presented in an integrated and interdisciplinary manner.
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| | (3-0-3) (Lec-Lab-Credit Hours)
The goal of this course is to learn the basic concepts commonly utilized in the processing of advanced materials with specific compositions and microstructures. Solid state diffusion mechanisms are described with emphasis on the role of point defects, the mobility of diffusing atoms, and their interactions. Macroscopic diffusion phenomena are analyzed by formulating partial differential equations and presenting their solutions. The relationships between processing and microstructure are developed on the basis of the rate of nucleation and growth processes that occur during condensation, solidification, and precipitation. Diffusionless phase transformations observed in certain metallic and ceramic materials are discussed.
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| | (3-0-3) (Lec-Lab-Credit Hours)
This course covers the environmental and health aspects of nanotechnology. It presents an overview of nanotechnology along with characterization and properties of nanomaterials. The course material covers the biotoxicity and ecotoxicity of nanomaterials. A sizable part of the course is devoted to discussions about the application of nanotechnology for environmental remediation along with discussions about fate and transport of nanomaterials. Special emphasis is given to risk assessment and risk management of nanomaterials, ethical and legal aspects of nanotechnology, and nano-industry and nano-entrepreneurship.
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| | (3-0-3) (Lec-Lab-Credit Hours)
This course provides an overview and industrial perspectives regarding downstream separation in drug substance development and manufacturing. Basic principles and practical applications of unit operations most commonly employed in the pharmaceutical industry will be discussed, including extraction, absorption, membrane, distillation, crystallization, filtration, and drying. Examples will be discussed to illustrate the intrinsic relationship between process development, equipment selection, and scale-up success.
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| | (3-0-3) (Lec-Lab-Credit Hours)
Lectures, demonstrations, and laboratory experiments, selected from among the following topics, depending on student interest: vacuum technology; thin-film preparation; scanning electron microscopy; infrared spectroscopy and ellipsometry; electron spectroscopy; Auger, photoelectron, and LEED; ion spectroscopies; SIMS, IBS, and field emission; surface properties-area, roughness, and surface tension.
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| | (3-0-3) (Lec-Lab-Credit Hours)
Upon completion of this course, students will be able to demonstrate an understanding of the major classes of engineering materials, their principal properties, and design requirements that serve as both the basis for materials selection, as well as for the ongoing development of new materials. This course is substantially differentiated from introductory materials courses by its very specific focus on materials whose use puts them in direct contact with physiological systems. Thus, the course begins with brief sections on inflammatory response, thrombosis, infection, and device failure. It then concentrates on developing the fundamental materials science and engineering concepts underlying the structure-property relationships in both synthetic and natural polymers, metals and alloys, and ceramics relevant to in vivo medical device technology.
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| | (3-0-3) (Lec-Lab-Credit Hours)
This course follows the introductory course and covers advanced topics in the design, modeling, and fabrication of micro and nano electromechanical systems. The materials will be broad and multidisciplinary including: review of micro and nano electromechanical systems, dimensional analysis and scaling, thermal, transport, fluids, microelectronics, feedback control, noise, and electromagnetism at the micro and nanoscales; the modeling of a variety of new MEMS/NEMS devices; and alternative approaches to the continuum mechanics theory. The goal will be achieved through a combination of lectures, case studies, individual homework assignments, and design projects carried out in teams.
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| | | (3-0-3) (Lec-Lab-Credit Hours)
The course covers recent advances in macromolecular science, including polyelectrolytes and water-soluble polymers, synthetic and biological macromolecules at surfaces, self-assembly of synthetic and biological macromolecules, and polymers for biomedical applications.
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| | (3-0-3) (Lec-Lab-Credit Hours)
Topics at the interface of polymer chemistry and biomedical sciences, focusing on areas where polymers have made a particularly strong contribution, such as in biomedical sciences and pharmaceuticals. Synthesis and properties of biopolymers; biomaterials; nanotechnology smart polymers; functional applications in biotechnology, tissue and cell engineering; and biosensors and drug delivery.
Prerequisites:
CH 244
(3-0-3)(Lec-Lab-Credit Hours)
Continuation of CH 243; reactions of aromatic compounds; infrared and nuclear magnetic resonance spectroscopy.
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| | (3-0-3) (Lec-Lab-Credit Hours)
This course will provide a comprehensive introduction to the rapidly developing field of nanomedicine and discuss the application of nanoscience and nanotechnology in medicine such as, in diagnosis, imaging and therapy, surgery, and drug delivery.
Prerequisites:
NANO 600
(3-0-3)(Lec-Lab-Credit Hours)
This course deals with the fundamentals and applications of nanoscience and nanotechnology. Size-dependent phenomena, ways and means of designing and synthesizing nanostructures, and cutting-edging applications will be presented in an integrated and interdisciplinary manner.
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| | (3-0-3) (Lec-Lab-Credit Hours)
As an introduction to micro/nano fluidics, course topics include basic fluid mechanical theories, experimental techniques, fabrication techniques and applications of micro/nano fluidics. The theory part will cover continuum fluid mechanics at micro/nano scales, molecular approaches, capillary effects, electrokinetic flows, acoustofluidics and optofluidics. The experimental part will cover micro/nano rheology and particle image velocimetry. The fabrication part will cover materials and machining techniques for micro/nano fluidic devices. The application part will cover micro/nano fluidic devices for flow control, life sciences and chemistry. As a term project, individual students are required to perform a case study for their own selected topic in micro/nano fluidics, to conduct a literature survey/summary and to propose/analyze their own new design idea of a micro/nano fluidic devices by utilizing the knowledge obtained throughout the course.
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| | (3-0-3) (Lec-Lab-Credit Hours)
A survey course covering the chemical, biological and material science aspects of interfacial phenomena. Applications to adhesion, biomembranes, colloidal stability, detergency, lubrication, coatings, fibers and powders - where surface properties play an important role.
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| | (3-0-3) (Lec-Lab-Credit Hours)
This course describes the application of nano- and micro-fabrication methods to build tools for exploring the mysteries of biological systems. It is a graduate-level course that will cover the basics of biology and the principles and practice of nano- and microfabrication techniques, with a focus on applications in biomedical and biological research.
Prerequisites:
NANO 600
(3-0-3)(Lec-Lab-Credit Hours)
This course deals with the fundamentals and applications of nanoscience and nanotechnology. Size-dependent phenomena, ways and means of designing and synthesizing nanostructures, and cutting-edging applications will be presented in an integrated and interdisciplinary manner.
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| | (3-0-3) (Lec-Lab-Credit Hours)
This advanced course covers the mechanism and biological role of signal transduction in mammalian cells. Topics included are extracellular regulatory signals, intracellular signal transduction pathways, role of tissue context in the function of cellular regulation, and examples of biological processes controlled by specific cellular signal transduction pathways.
Prerequisites:
CH 381
(3-3-4)(Lec-Lab-Credit Hours)
The structure and function of the cell and its subcellular organelles is studied. Biological macromolecules, enzymes, biomembranes, biological transport, bioenergetics, DNA replication, protein synthesis and secretion, motility, and cancer are covered. Cell biology experiments and interactive computer simulation exercises are conducted in the laboratory.
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(3-3-4)(Lec-Lab-Credit Hours)
Introduction to the study of molecular basis of inheritance. Starts with classical Mendelian genetics and proceeds to the study and function of DNA, gene expression and regulation in prokaryotes and eukaryotes, genome dynamics and the role of genes in development, and cancer. All topics include discussions of current research advances. Accompanied by laboratory section that explores the lecture topics in standard wet laboratory experiments and in computer simulations.
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| | (3-0-3) (Lec-Lab-Credit Hours)
This course is intended to introduce the concept of electronic energy band engineering for device applications. Topics to be covered are electronic energy bands, optical properties, electrical transport properties of multiple quantum wells, superlattices, quantum wires, and quantum dots; mesoscopic systems, applications of such structures in various solid state devices, such as high electron mobility, resonant tunneling diodes, and other negative differential conductance devices, double-heterojunction injection lasers, superlattice-based infrared detectors, electron-wave devices (wave guides, couplers, switching devices), and other novel concepts and ideas made possible by nano-fabrication technology. Fall semester. Typical text: M. Jaros, Physics and Applications of Semiconductor Microstructures; G. Bastard, Wave Mechanics Applied to Semiconductor Heterostructures.
Prerequisites:
PEP 503
(3-0-3)(Lec-Lab-Credit Hours)
Description of simple physical models which account for electrical conductivity and thermal properties of solids. Basic crystal lattice structures, X-ray diffraction and dispersion curves for phonons and electrons in reciprocal space. Energy bands, Fermi surfaces, metals, insulators, semiconductors, superconductivity and ferromagnetism. Fall semester. Typical text: Kittel, Introduction to Solid State Physics.
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(3-0-3)(Lec-Lab-Credit Hours)
This course is meant to serve as an introduction to formal quantum mechanics as well as to apply the basic formalism to several generic and important applications.
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| | (3-0-3) (Lec-Lab-Credit Hours)
This course deals with the principles of light interactions with biological and biomedical-relevant systems. The enabling aspects of nanotechnology for advanced biosensing, medical diagnosis, and therapeutic treatment will be discussed.
Prerequisites:
NANO 600
(3-0-3)(Lec-Lab-Credit Hours)
This course deals with the fundamentals and applications of nanoscience and nanotechnology. Size-dependent phenomena, ways and means of designing and synthesizing nanostructures, and cutting-edging applications will be presented in an integrated and interdisciplinary manner.
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| | (0-0-3) (Lec-Lab-Credit Hours)
Lectures by department faculty, guest speakers and doctoral students on recent research.
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| | (3-0-3) (Lec-Lab-Credit Hours)
This graduate course will introduce the applications of multiscale theory and computational techniques in the fields of materials and mechanics. Students will obtain fundamental knowledge on homogenization and heterogeneous materials, and be exposed to various sequential and concurrent multiscale techniques. The first half of the course will be focused on the homogenization theory and its applications in heterogeneous materials. In the second half multiscale computational techniques will be addressed through multiscale finite element methods and atomistic/continuum computing. Students are expected to develop their own course projects based on their research interests and the relevant topics learned from the course.
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| | (3-0-3) (Lec-Lab-Credit Hours)
Progress in the technology of nanostructure growth; space and time scales; quantum confined systems; quantum wells, coupled wells, and superlattices; quantum wires and quantum dots; electronic states; magnetic field effects; electron-phonon interaction; and quantum transport in nanostructures: Kubo formalism and Butikker-Landau formalism; spectroscopy of quantum dots; Coulomb blockade, coupled dots, and artificial molecules; weal localization; universal conductance fluctuations; phase-breaking time; theory of open quantum systems: fluctuation-dissipation theorem; and applications to quantum transport in nanostructures.
Prerequisites:
PEP 554
(3-0-3)(Lec-Lab-Credit Hours)
Basic concepts of quantum mechanics, states, operators; time development of Schrödinger and Heisenberg pictures; representation theory; symmetries; perturbation theory; systems of identical particles, L-S and j-j coupling; fine and hyperfine structure; scattering theory; molecular structure. Spring semester. Typical texts: Gottfried, Quantum Mechanics, Schiff, Quantum Mechanics.
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(3-0-3)(Lec-Lab-Credit Hours)
Crystal symmetry. Space-group-theory analysis of normal modes of lattice vibration, phonon dispersion relations, and Raman and infrared activity. Crystal field splitting of ion energy level and transition selection rules. Bloch theorem and calculation of electronic energy bands through tight binding and pseudopotential methods for metals and semiconductors and Fermi surfaces. Transport theory, electrical conduction, thermal properties, cyclotron resonance, de Haas van Alfen, and Hall effects. Dia-, para-, and ferro-magnetism and magnon spinwaves. Spring semester. Typical texts: Callaway, Quantum Theory of Solid State; Ashcroft and Mermin, Solid State Physics; and Kittel, Quantum Theory of Solids.
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| Chemistry & Chemical Biology |
| | (0-0-3) (Lec-Lab-Credit Hours)
Review of undergraduate physical chemistry by means of problem solving; atomic spectra; structure of atoms and molecules; thermodynamics; changes of state; solutions; chemical equilibrium; kinetic theory of gases; chemical kinetics, and electrochemistry.
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| | (1-0-1) (Lec-Lab-Credit Hours)
A course for advanced undergraduate and beginning graduate students in the sciences, especially chemistry and chemical biology, focusing on the ethical problems unique to the chemical profession. Special emphasis will be given to situations in which there is not a simple correct answer but only a number of imperfect alternatives. Class discussion of case studies. This course is recommended by the Committee on Professional Training of the American Chemical Society as a component of ACS Certification. It is not a course in general theories of ethics, nor a course treating the problems of Bioethics, such as human subjects and animal testing and DNA modification, but a course on problems encountered in the chemical profession.
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| | (3-0-3) (Lec-Lab-Credit Hours)
The elements of quantum mechanics are developed and applied to chemical systems. Valence bond theory and molecular orbital theory of small molecules; introduction to group theory for molecular symmetry; fundamental aspects of chemical bonding, and molecular spectra.
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| | (0-0-3) (Lec-Lab-Credit Hours)
See course description under MT524.
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| | (3-0-3) (Lec-Lab-Credit Hours)
Lectures, demonstrations and laboratory experiments, selected from among the following topics, depending on student interest: vacuum technology; thin-film preparation; scanning electron microscopy; infrared spectroscopy, ellipsometry: electron spectroscopies-Auger, photoelectron, LEED; ion spectroscopies SIMS, IBS, field emission; surface properties-area, roughness, and surface tension. Alternate years.
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| | (3-0-3) (Lec-Lab-Credit Hours)
Your needs and interests will be considered in the assignment of typical advanced preparations, small research problems and special operations. Fall and Spring semesters, by request.
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| | (3-0-3) (Lec-Lab-Credit Hours)
Your needs and interests will be considered in the assignment of typical advanced preparations, small research problems and special operations. Fall and Spring semesters, by request.
Prerequisites:
CH 540 Advanced Organic Laboratory I
(3-0-3)(Lec-Lab-Credit Hours)
Your needs and interests will be considered in the assignment of typical advanced preparations, small research problems and special operations. Fall and Spring semesters, by request.
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| | (3-0-3) (Lec-Lab-Credit Hours)
Most processes in petroleum and chemical industries utilize catalytic reactions. Moreover, many emerging technologies in the energy sector and in green chemistry for sustainability rely on catalysis. This course provides the fundamentals of synthesis, characterization and testing of catalytic materials with an emphasis on metal and metal oxide nanoparticles, the most widely used class of catalysts. Methodologies for development of molecular-level reaction mechanisms, material structure-activity relations and kinetic models are described. The course is essential for anyone planning a career in the chemical industry. It is recommended for all professionals working with nanoparticles and also with diverse applications where the solid-gas interface is important.
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| | (3-0-3) (Lec-Lab-Credit Hours)
Primarily a laboratory course, with some lecture presenting the principles and applications of contemporary instrumental analytical methods, with a focus on spectroscopy and separations. Laboratory practice explores ultraviolet, visible and infrared spectrophotometry, atomic absorption spectroscopy, nuclear magnetic resonance spectrometry, gas-liquid and high-performance liquid chromatography, and capillary electrophoresis. These instrumental techniques are utilized for quantitative and qualitative analyses of organic, inorganic, biological and environmntal samples.
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| | (3-0-3) (Lec-Lab-Credit Hours)
Course covers the following topics: Structure and physical, chemical and biological attributes of biologics. Product stability, pharmacokinetics, delivery. Critical quality attributes of Pioneer Drugs and Biogenerics. Fundamentals of nucleic acid and protein structure and function. Genetic engineering tools. Modern production vectors and hosts. Cell line and media selection and optimization. Cell-bank characterization and stability. Upstream processes. Culture, fermentation and scale-up. Critical upstream process parameters, regulatory controls and validation. Rapid vaccine manufacturing and monoclonal antibody case studies. Prerequisites: Students must have taken at least one course in organic chemistry and one course in biochemistry, molecular biology, or genetics, or equivalent background as determined by instructor.
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| | (3-0-3) (Lec-Lab-Credit Hours)
Discussions include metabolic pathways in biosynthesis and catabolism of biomolecules, including carbohydrates, proteins, lipids, and nucleic acids. The hormonal regulation of metabolism, as well as vitamin metabolism, is presented.
Prerequisites:
CH 242 Organic Chemistry II
(0-0-3)(Lec-Lab-Credit Hours)
Continuation of Ch 241; reactions of aromatic compounds; infrared and nuclear magnetic resonance spectroscopy; laboratory work in synthesis, spectroscopy, and chromatographic separation techniques.
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| | (3-0-3) (Lec-Lab-Credit Hours)
Discusses the physical and structural chemistry of proteins and nucleotides, as well as the functional role these molecules play in biochemistry. Extensive use of known X-ray structural information will be used to visualize the three-dimensional structure of these biomolecules. This structural information will be used to relate the molecules to known functional information.
Prerequisites:
CH 244 Organic Chemistry II
(3-0-3)(Lec-Lab-Credit Hours)
Continuation of CH 243; reactions of aromatic compounds; infrared and nuclear magnetic resonance spectroscopy.
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| | (3-0-3) (Lec-Lab-Credit Hours)
The relationship of the chemical and physical structure of biological macromolecules to their biological functions as derived from osmotic pressure, viscosity, light and X-ray scatting, diffusion, ultracentrifugation, and electrophoresis. The course is subdivided into: 1) properties, functions, and interrelations of biological macromolecules, e.g., polysaccharides, proteins, and nucleic acids; 2) correlation of physical properties of macromolecules in solution; 3) conformational properties of proteins and nucleic acids; and 4) aspects of metal ions in biological systems.
Prerequisites:
CH 421 Chemical Dynamics
(3-4-4)(Lec-Lab-Credit Hours)
Chemical kinetics, solution theories with applications to separation processes, electrolytes, polyelectrolytes, regular solutions and phase equilibria, and laboratory practice in the measurements of physical properties and rate processes.
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| | (3-0-3) (Lec-Lab-Credit Hours)
Fundamentals of control processes governing physiological systems analyzed at the cellular and molecular level. Biological signal transduction and negative feedback control of metabolic processes. Examples from sensory, nervous, cardiovascular, and endocrine systems. Deviations that give rise to abnormal states; their detection, and the theory behind the imaging and diagnostic techniques such as MRI, PET, SPECT; and the design and development of therapeutic drugs. The principles, uses, and applications of biomaterials and tissue engineering techniques; and problems associated with biocompatibility. Students (or groups of students) are expected to write and present a term project.
Prerequisites:
CH 382 Biological Systems
(3-3-4)(Lec-Lab-Credit Hours)
Physiochemical principles underlying the coordinated function in multicellular organisms are studied. Electrical properties of biological membranes, characteristics of tissues, nerve-muscle electrophysiology, circulatory, respiratory, endocrine, digestive, and excretory systems are covered. Computer simulation experiments and data acquisition methods to evaluate and monitor human physiological systems are conducted in the laboratory.
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| | (3-0-3) (Lec-Lab-Credit Hours)
A systematic treatment of the bonding and reactivity of inorganic substances; molecular shape and electron charge distribution of main-group and coordination compounds, including valence-bond theory and a group theoretical approach to molecular orbital theory; organometallic chemistry; the solid state; and the role of inorganic compounds in biological processes and the environment.
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| | (3-0-3) (Lec-Lab-Credit Hours)
Applications of the laws of thermodynamics to solutions, electrolytes and polyelectrolytes, binding, and biological systems; statistical thermodynamics is developed and applied to spectroscopy and transition state theory; and chemical kinetics of simple and complex reactions, enzyme and heterogeneous catalysis, and theories of reaction rates.
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| | (3-0-3) (Lec-Lab-Credit Hours)
Theorems and postulates of quantum mechanics; operator relationships; solutions of the Schrödinger equation for model systems; variation and perturbation methods; pure spin states; Hartree-Fock self-consistent field theory; and applications to many-electron atoms and molecules.
Prerequisites:
CH 520 Advanced Physical Chemistry
(3-0-3)(Lec-Lab-Credit Hours)
The elements of quantum mechanics are developed and applied to chemical systems. Valence bond theory and molecular orbital theory of small molecules; introduction to group theory for molecular symmetry; fundamental aspects of chemical bonding, and molecular spectra.
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Quantum Mechanics II
(3-0-3)(Lec-Lab-Credit Hours)
Basic concepts of quantum mechanics, states, operators; time development of Schrödinger and Heisenberg pictures; representation theory; symmetries; perturbation theory; systems of identical particles, L-S and j-j coupling; fine and hyperfine structure; scattering theory; molecular structure. Spring semester. Typical texts: Gottfried, Quantum Mechanics, Schiff, Quantum Mechanics.
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| | (3-0-3) (Lec-Lab-Credit Hours)
Theoretical foundations of spectroscopic methods and their application to the study of atomic and molecular structure and properties; theory of absorption and emission of radiation; line spectra of complex atoms: group theory; rotational, vibrational, and electronic spectroscopy of diatomic and polyatomic molecules; infrared, Raman, uv-vis spectroscopy; laser spectroscopy and applications; photoelectron spectroscopy; multi-photon processes. Also offered as PEP 722. By request.
Prerequisites:
CH 520 Advanced Physical Chemistry
(3-0-3)(Lec-Lab-Credit Hours)
The elements of quantum mechanics are developed and applied to chemical systems. Valence bond theory and molecular orbital theory of small molecules; introduction to group theory for molecular symmetry; fundamental aspects of chemical bonding, and molecular spectra.
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Quantum Mechanics II
(3-0-3)(Lec-Lab-Credit Hours)
Basic concepts of quantum mechanics, states, operators; time development of Schrödinger and Heisenberg pictures; representation theory; symmetries; perturbation theory; systems of identical particles, L-S and j-j coupling; fine and hyperfine structure; scattering theory; molecular structure. Spring semester. Typical texts: Gottfried, Quantum Mechanics, Schiff, Quantum Mechanics.
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| | (3-0-3) (Lec-Lab-Credit Hours)
A detailed discussion of the kinetics and mechanism of complex reactions in the gaseous and liquid phases; topics include: stationary and nonstationary conditions; chain reactions, photo and radiation-induced reactions, and reaction rate theories. By request.
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| | (3-0-3) (Lec-Lab-Credit Hours)
Classical and quantum mechanical preliminaries; derivation of the laws of thermodynamics; applications to monoatomic and polyatomic gases and to gaseous mixtures; systems of dependent particles with applications to the crystalline solid, the imperfect ga, s and the cooperative phenomena; electric and magnetic fields; and degenerate gases. By request.
Prerequisites:
CH 620 Chemical Thermodynamics and Kinetics
(3-0-3)(Lec-Lab-Credit Hours)
Applications of the laws of thermodynamics to solutions, electrolytes and polyelectrolytes, binding, and biological systems; statistical thermodynamics is developed and applied to spectroscopy and transition state theory; and chemical kinetics of simple and complex reactions, enzyme and heterogeneous catalysis, and theories of reaction rates.
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| | (3-0-3) (Lec-Lab-Credit Hours)
An advanced course in the chemistry of carbon compounds, with special reference to polyfunctional compounds, heterocycles, techniques of literature survey, stereochemical concepts, and physical tools for organic chemists. Fall semester.
Prerequisites:
CH 242 Organic Chemistry II
(0-0-3)(Lec-Lab-Credit Hours)
Continuation of Ch 241; reactions of aromatic compounds; infrared and nuclear magnetic resonance spectroscopy; laboratory work in synthesis, spectroscopy, and chromatographic separation techniques.
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| | (3-0-3) (Lec-Lab-Credit Hours)
An advanced course in the chemistry of carbon compounds, with special reference to polyfunctional compounds, heterocycles, techniques of literature survey, stereochemical concepts, and physical tools for organic chemists. Spring semester.
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| | (3-0-3) (Lec-Lab-Credit Hours)
A survey of important synthetic methods with emphasis on stereochemistry and reaction mechanism.
Prerequisites:
CH 242 Organic Chemistry II
(0-0-3)(Lec-Lab-Credit Hours)
Continuation of Ch 241; reactions of aromatic compounds; infrared and nuclear magnetic resonance spectroscopy; laboratory work in synthesis, spectroscopy, and chromatographic separation techniques.
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| | (3-0-3) (Lec-Lab-Credit Hours)
Structure, synthesis, and biogenesis of antibiotics, alkaloids, hormones, and other natural products.
Prerequisites:
CH 244 Organic Chemistry II
(3-0-3)(Lec-Lab-Credit Hours)
Continuation of CH 243; reactions of aromatic compounds; infrared and nuclear magnetic resonance spectroscopy.
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| | (3-0-3) (Lec-Lab-Credit Hours)
Discussion at the molecular level of drug receptor interaction, influence of stereochemistry and physiochemical properties on drug action, pharmacological effects of structural features, mechanism of drug action, metabolic rate of drugs in animals and man, and drug design. The application of newer physical tools and recent advances in methods for pharmacological studies will be emphasized.
Prerequisites:
CH 244 Organic Chemistry II
(3-0-3)(Lec-Lab-Credit Hours)
Continuation of CH 243; reactions of aromatic compounds; infrared and nuclear magnetic resonance spectroscopy.
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| | (3-0-3) (Lec-Lab-Credit Hours)
An intensive course on the interpretation of spectroscopic data; emphasis is on the use of modern spectroscopic techniques, such as NMR (13C, D, 15N, and H), mass (including CI), laser-Raman, ESCA, ORD, CD, IR, and UV for structure elucidation. Special attention is given to the application of computer technology in spectral work. A course designed for practicing chemists in analytical, organic, physical, and biomedical areas. Extensive problem solving. No laboratory.
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| | (3-0-3) (Lec-Lab-Credit Hours)
Advanced treatment of the theory and practice of spectrometric methods (mass spectrometry, nuclear magnetic resonance, etc.) and electroanalytical methods with emphasis on Fourier Transform techniques (FTIR, FTNMR, etc.) and hyphenated methods (gc-ms, etc.), the instrument-sample interaction, and signal sampling. A survey of computational methods, such as factor analysis and other chemometric methods is also included.
Prerequisites:
CH 362 Instrumental Analysis I - Spectroscopy and Chromatography
(3-4-4)(Lec-Lab-Credit Hours)
Theoretical and experimental approach to spectroscopy and chromatography. Includes ultraviolet, visible and infrared absorption by molecules, emission spectroscopy, nuclear magnetic resonance, mass spectroscopy and gas-liquid and high-performance chromatography.
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| | (3-0-3) (Lec-Lab-Credit Hours)
Your needs and interests are considered in the assignment of work on one or more of the following: NMR spectrometry, mass spectrometry, electrochemical methods, infrared, ultraviolet, and visible spectrophotometry.
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| | (3-0-3) (Lec-Lab-Credit Hours)
An advanced course applying principles and theory to problems in chemical analysis. Theory of separations, including distillation, chromatography, and ultracentrifugation; heterogeneity and surface effects; and sampling and its problems.
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| | (3-0-3) (Lec-Lab-Credit Hours)
A practical treatment of the mechanical, electronic, and optical devices used in the construction of instruments for research and chemical analysis and control; motors, light sources and detectors, servomechanisms, electronic components and test equipment, vacuum and pressure measuring devices, and overall design concepts are among the topics treated.
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| | (3-0-3) (Lec-Lab-Credit Hours)
Discusses computational chemistry topics, including energy minimization, molecular dynamics, solvation mechanics, and electronic structure calculations. Applications in drug design and receptors will be discussed.
Prerequisites:
CH 321 Thermodynamics
(3-0-3)(Lec-Lab-Credit Hours)
Laws of thermodynamics, thermodynamic functions, and the foundations of statistical thermodynamics. The chemical potential is applied to phase equilibria, chemical reaction equilibria, and solution theory, for both ideal and real systems.
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| | (0-0-3) (Lec-Lab-Credit Hours)
Application of chemometric techniques to problems in analytical, physical and organic chemistry, with emphasis on spectroscopic measurements. Includes optimization, analysis of variance, pattern recognition, factor analysis, experimental design, etc.
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| | (3-4-4) (Lec-Lab-Credit Hours)
A comprehensive hands-on course covering both fundamentals and modern aspects of mass spectrometry, with emphasis on biological and biochemical applications. Topics include: contemporary methods of gas phase ion formation [electron ionization (EI), chemical ionization (CI), inductively coupled plasma (ICP), fast atom bombardment (FAB), plasma desorption (PD), electrospray (ESI), atmospheric pressure chemical ionization (APCI), matrix assisted laser desorption ionization (MALDI), detection (electron and photomultipliers, and array detectors), and mass analysis [magnetic deflection, quadrupole, ion trap, time of flight (TOF), and Fourier-transform (FTMS)]. Detailed interpretation of organic mass spectra for structural information, with special emphasis on even-electron-ion fragmentation. Qualitative and quantitative applications in environmental, biological, pharmacological, forensic, and geochemical sciences.
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| | (3-0-3) (Lec-Lab-Credit Hours)
Topics at the interface of biology and computer technology will be discussed, including molecular sequence analysis, phylogeny generation, biomolecular structure simulation, and modeling of site-directed mutagenesis.
Prerequisites:
CH 321 Thermodynamics
(3-0-3)(Lec-Lab-Credit Hours)
Laws of thermodynamics, thermodynamic functions, and the foundations of statistical thermodynamics. The chemical potential is applied to phase equilibria, chemical reaction equilibria, and solution theory, for both ideal and real systems.
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Biochemistry I - Cellular Metabolism and Regulation
(3-0-3)(Lec-Lab-Credit Hours)
Discussions include metabolic pathways in biosynthesis and catabolism of biomolecules, including carbohydrates, proteins, lipids, and nucleic acids. The hormonal regulation of metabolism, as well as vitamin metabolism, is presented.
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| | | (3-0-3) (Lec-Lab-Credit Hours)
Mechanisms and kinetics of organic and inorganic polymerization reactions; condensation, free radical and ionic addition, and stereoregular polymerizations; copolymerizations; and the nature of chemical bonds and the resulting physical properties of high polymers.
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| | (3-0-3) (Lec-Lab-Credit Hours)
Physio-chemical aspects of polymers, molecular weight distributions, solution characterization and theories, polymer chain configuration, thermodynamics of polymer solutions, the amorphous state, and the crystalline state.
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| | (3-0-3) (Lec-Lab-Credit Hours)
The course covers recent advances in macromolecular science, including polyelectrolytes and water-soluble polymers, synthetic and biological macromolecules at surfaces, self-assembly of synthetic and biological macromolecules, and polymers for biomedical applications.
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| | (3-0-3) (Lec-Lab-Credit Hours)
Recent developments in polymer science will be discussed, e.g., physical measurements, polymer characterization, polymerization kinetics, and morphology. Topics will vary from year to year and specialists will participate.
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| | (3-0-3) (Lec-Lab-Credit Hours)
Topics at the interface of polymer chemistry and biomedical sciences, focusing on areas where polymers have made a particularly strong contribution, such as in biomedical sciences and pharmaceuticals . Synthesis and properties of biopolymers; biomaterials; nanotechnology smart polymers; functional applications in biotechnology, tissue and cell engineering; and biosensors and drug delivery.
Prerequisites:
CH 244
(3-0-3)(Lec-Lab-Credit Hours)
Continuation of CH 243; reactions of aromatic compounds; infrared and nuclear magnetic resonance spectroscopy.
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| | (3-0-3) (Lec-Lab-Credit Hours)
Discussions in medical, industrial, and environmental microbiology will include bacteriology, virology, mycology, parasitology, and infectious diseases. Includes experimental laboratory instruction.
Prerequisites:
CH 382
(3-3-4)(Lec-Lab-Credit Hours)
Physiochemical principles underlying the coordinated function in multicellular organisms are studied. Electrical properties of biological membranes, characteristics of tissues, nerve-muscle electrophysiology, circulatory, respiratory, endocrine, digestive, and excretory systems are covered. Computer simulation experiments and data acquisition methods to evaluate and monitor human physiological systems are conducted in the laboratory.
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| | (3-0-3) (Lec-Lab-Credit Hours)
Students will work actively in small collaborative groups to solve a unique research project that encompasses the purification, analysis of purity, kinetics, and structure-function analysis of a novel recombinant protein. Techniques in protein purification, gel electrophoresis, peptide digest separation, ligand binding, steady-state and stopped-flow kinetics, and molecular simulation will be explored.
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| | (3-0-3) (Lec-Lab-Credit Hours)
This laboratory course introduces essential techniques in molecular biology and genetic engineering in a project format. The course includes aseptic technique and the handling of microbes; isolation and purification of nucleic acids; construction, selection and analysis of recombinant DNA molecules; restriction mapping; immobilization and hybridization of nucleic acids; and labeling methods of nucleic acid probes.
Prerequisites:
CH 484
(3-3-4)(Lec-Lab-Credit Hours)
Introduction to the study of molecular basis of inheritance. Starts with classical Mendelian genetics and proceeds to the study and function of DNA, gene expression and regulation in prokaryotes and eukaryotes, genome dynamics and the role of genes in development, and cancer. All topics include discussions of current research advances. Accompanied by laboratory section that explores the lecture topics in standard wet laboratory experiments and in computer simulations.
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| | (3-0-3) (Lec-Lab-Credit Hours)
A few topics of timely interest will be treated in depth,; recent chemical developments will be surveyed in fields such as antibiotics, cancer chemotherapy, CNS agents, chemical control of fertility, steroids and prostaglandins in therapy, etc.
Prerequisites:
CH 242
(0-0-3)(Lec-Lab-Credit Hours)
Continuation of Ch 241; reactions of aromatic compounds; infrared and nuclear magnetic resonance spectroscopy; laboratory work in synthesis, spectroscopy, and chromatographic separation techniques.
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| | (3-0-3) (Lec-Lab-Credit Hours)
The cells and molecules of the immune system and their interaction and regulation; the cellular and genetic components of the immune response, the biochemistry of antigens and antibodies, the generation of antibody diversity, cytokines, hypersensitivities, and immunodeficiencies (i.e. AIDS); and transplants and tumors. Use of antibodies in currently emerging immunodiagnostic techniques such as ELISA, disposable kits, molecular targets, and development of vaccines utilizing molecular biological techniques, such as recombinant and subunit vaccines. Students (or groups of students) are expected to write and present a term project.
Prerequisites:
CH 381
(3-3-4)(Lec-Lab-Credit Hours)
The structure and function of the cell and its subcellular organelles is studied. Biological macromolecules, enzymes, biomembranes, biological transport, bioenergetics, DNA replication, protein synthesis and secretion, motility, and cancer are covered. Cell biology experiments and interactive computer simulation exercises are conducted in the laboratory.
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| | (3-0-3) (Lec-Lab-Credit Hours)
This course is a modern approach to the study of heredity through molecular biology. Primary emphasis is on nucleic acids, the molecular biology of gene expression, molecular recognition and signal transduction, and bacterial and viral molecular biology. The course will also discuss recombinant DNA technology and its impact on science and medicine.
Prerequisites:
CH 484
(3-3-4)(Lec-Lab-Credit Hours)
Introduction to the study of molecular basis of inheritance. Starts with classical Mendelian genetics and proceeds to the study and function of DNA, gene expression and regulation in prokaryotes and eukaryotes, genome dynamics and the role of genes in development, and cancer. All topics include discussions of current research advances. Accompanied by laboratory section that explores the lecture topics in standard wet laboratory experiments and in computer simulations.
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| | (3-0-3) (Lec-Lab-Credit Hours)
A discussion of the theories underlying various techniques of molecular biology which are used in the biotechnology industry. Topics include all recombinant DNA techniques; DNA isolation and analysis; library construction and screening; cloning; DNA sequencing; hybridization and other detection methods; RNA isolation and analysis; protein isolation and analysis (immunoassay, ELISA, etc.); transgenic and ES cell methods; electrophoresis (agarose, acrylamide, two dimensional, and SDS-PAGE); column chromatography; and basic cell culture including transfection and expression systems.
Prerequisites:
CH 381
(3-3-4)(Lec-Lab-Credit Hours)
The structure and function of the cell and its subcellular organelles is studied. Biological macromolecules, enzymes, biomembranes, biological transport, bioenergetics, DNA replication, protein synthesis and secretion, motility, and cancer are covered. Cell biology experiments and interactive computer simulation exercises are conducted in the laboratory.
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| | (3-0-3) (Lec-Lab-Credit Hours)
Laboratory practice in modern biological research will be explored. Techniques involving gene and protein cellular probes, ELISA, mammalian cell culturing, cell cycle determination, differential centrifugation, electron microscopy, and fluorescent cellular markets will be addressed. Laboratory fee $60.
Prerequisites:
CH 381
(3-3-4)(Lec-Lab-Credit Hours)
The structure and function of the cell and its subcellular organelles is studied. Biological macromolecules, enzymes, biomembranes, biological transport, bioenergetics, DNA replication, protein synthesis and secretion, motility, and cancer are covered. Cell biology experiments and interactive computer simulation exercises are conducted in the laboratory.
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| | (3-0-3) (Lec-Lab-Credit Hours)
This advanced course covers the mechanism and biological role of signal transduction in mammalian cells. Topics included are extracellular regulatory signals, intracellular signal transduction pathways, role of tissue context in the function of cellular regulation, and examples of biological processes controlled by specific cellular signal transduction pathways.
Prerequisites:
CH 381
(3-3-4)(Lec-Lab-Credit Hours)
The structure and function of the cell and its subcellular organelles is studied. Biological macromolecules, enzymes, biomembranes, biological transport, bioenergetics, DNA replication, protein synthesis and secretion, motility, and cancer are covered. Cell biology experiments and interactive computer simulation exercises are conducted in the laboratory.
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(3-3-4)(Lec-Lab-Credit Hours)
Introduction to the study of molecular basis of inheritance. Starts with classical Mendelian genetics and proceeds to the study and function of DNA, gene expression and regulation in prokaryotes and eukaryotes, genome dynamics and the role of genes in development, and cancer. All topics include discussions of current research advances. Accompanied by laboratory section that explores the lecture topics in standard wet laboratory experiments and in computer simulations.
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| | (3-0-3) (Lec-Lab-Credit Hours)
Systems biology is a new approach to complex biological problems. It uses a combination of the most modern techniques for comprehensive measurements of cells and molecules, combined with complex computer and mathematical modeling, to build up inclusive depictions of how living systems function. This course is an integrative approach to help comprehend dynamic biological systems. True understanding of systems biology requires a cross-disciplinary approach. Topics will include both a biological and computer science perspective taught by experts in each individual discipline. The course will cover introduction to advance biological subjects in cell biology and genetics followed by introduction to computer science methods including modeling and “bio-machine” features of systems biology. In class, we will also explore critical reading of current research.
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Epigenetics describes the inheritance of different functional states, which may have divergent phenotypic consequences, without any change in the sequence of DNA. This course will examine the molecular mechanisms and biological processes in which epigenetic modifications play an elemental role in inheritance. It will cover different biological mechanisms of the epigenetic machinery including: DNA methylation, histone tails, chromatin structure, nucleosome occupancy, heterochromatin assembly, gene silencing, siRNAs and miRNAs. The epigenetic profile of embryonic stem cells, cell differentiation, gene imprinting and X-chromosome inactivation will be examined as well as the relationship of epigenetics to cancers and ageing. Prerequisites: Undergraduate Genetics and Undergraduate Cell Biology.
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| | (3-0-3) (Lec-Lab-Credit Hours)
This course combines computational modeling with lab experience. The course is project based. Students will be able to choose from a pool of problems being actively researched at Stevens, understand how to obtain experimental data, design and implement a computational model, predict the behavior of the system being modeled, and use a second set of experimental results to validate the model.
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This course is designed for beginning graduate students and advanced undergraduate students with a particular enthusiasm for advanced cell biology. Overall, the course will present organelle biogenesis by first presenting past scientific strategies, theories, and findings in the field of cell biology and then relating these foundations to current investigations. Reviews of protein and lipid mediators important for organelle biogenesis are then presented followed by summaries focused on the nucleus, endoplasmic reticulum, Golgi apparatus, lysosome, mitochondria, and peroxisome. Each organelle will be extensively covered for sub-compartment biochemistry, isolation, and current research. Intensive classroom discussions focus on the experimental methods used, results obtained, interpretation of these results in the context of cell structure and function, and implications for further directions of studies in the field.
Prerequisites:
CH 381
(3-3-4)(Lec-Lab-Credit Hours)
The structure and function of the cell and its subcellular organelles is studied. Biological macromolecules, enzymes, biomembranes, biological transport, bioenergetics, DNA replication, protein synthesis and secretion, motility, and cancer are covered. Cell biology experiments and interactive computer simulation exercises are conducted in the laboratory.
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| | (1-0-0.5) (Lec-Lab-Credit Hours)
Lectures by department faculty, guest speakers, and doctoral students on recent research.
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International graduate students may arrange an educationally relevant internship or paying position off campus and receive Curricular Practical Training (CPT) credit via this course. Students must maintain their full time status while receiving CPT. Prior approval of the program director is required for enrollment. To justify enrollment, the student must have a concrete commitment from a specific employer for a specific project, and must provide to the program director for his/her approval a description of the project plus a statement from the employer that he/she intends to employ the student. This information must be provided to the program director with sufficient advance notice so that the program director has time to review the materials and determine if the project is appropriate. The project must be educationally relevant; i.e., it must help the student develop skills consistent with the goals of the educational program. During the semester, the student must submit written progress reports. At the end of the semester, the student must submit for grading a written report that describes his/her activities during that semester, even if the activity remains ongoing. The student must also present his/her activities in an accompanying oral presentation that is also graded. This is a one-credit course that may be repeated up to a total of three credits.
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| | (3-0-3) (Lec-Lab-Credit Hours)
Topics of current interest selected by you are to be investigated from an advanced point of view.
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Topics of current interest selected by you are to be investigated from an advanced point of view.
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Topics selected to coincide with research interests current in the department.
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Selected topics of current interest in the field of organic chemistry will be treated from an advanced point of view; recent developments will be surveyed in fields such as reaction mechanisms, physical methods in organic chemistry, natural products chemistry, biogenesis, etc.
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This advanced course in computational chemistry builds on the methods developed in CH 664. Students will analyze and design combinatorial libraries, develop SAR models, and generate calculated molecular properties. The hands-on course will use both PC and Silicon Graphics computers. Software, such as that from Oxford Molecular, Tripos, and Oracle will be used, as will MSI software, such as INSIGHT/DISCOVER, Catalyst, and Cerius 2.
Prerequisites:
CH 664
(3-0-3)(Lec-Lab-Credit Hours)
Discusses computational chemistry topics, including energy minimization, molecular dynamics, solvation mechanics, and electronic structure calculations. Applications in drug design and receptors will be discussed.
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Topics of current interest in biochemical research are discussed, such as: enzyme chemistry, biochemical genetics and development, cellular control mechanism, biochemistry of cell membranes, bioenergetics, and microbiology.
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Topics of current interest in biochemical research are discussed, such as: enzyme chemistry, biochemical genetics and development, cellular control mechanism, biochemistry of cell membranes, bioenergetics, and microbiology.
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| | (3-0-3) (Lec-Lab-Credit Hours)
Topics of timely interest will be treated in an interdisciplinary fashion; recent developments will be surveyed in fields such as biosynthesis, radioactive and stable isotope techniques, genesis of life chemicals, nucleic acids and replication, genetic defects, and metabolic errors.
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| | (0-0-3) (Lec-Lab-Credit Hours)
One to six credits. Limit of six credits for the degree of Master of Science.
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| | (0-0-3) (Lec-Lab-Credit Hours)
One to six credits. Limit of six credits for the degree of Doctor of Philosophy.
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| | (0-0-3) (Lec-Lab-Credit Hours)
For the degree of Master of Science, five to ten credits with departmental approval.
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| | (0-0-3) (Lec-Lab-Credit Hours)
Original experimental or theoretical research that may serve as the basis for the dissertation required for the degree of Doctor of Philosophy. The work will be carried out under the guidance of a faculty member. Hours and credits to be arranged.
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Chemistry, Chemical Biology & Biomedical Engineering
Department
Francis T. Jones, Director |
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