Upon completion of this course, students will be able to demonstrate an understanding of the major classes of engineering materials, their principal properties, and design requirements that serve as both the basis for materials selection, as well as for the ongoing development of new materials. This course is substantially differentiated from introductory materials courses by its very specific focus on materials whose use puts them in direct contact with physiological systems. Thus, the course begins with brief sections on inflammatory response, thrombosis, infection, and device failure. It then concentrates on developing the fundamental materials science and engineering concepts underlying the structure-property relationships in both synthetic and natural polymers, metals and alloys, and ceramics relevant to in vivo medical-device technology.
This course will provide a comprehensive introduction to the rapidly developing field of nanomedicine, and discuss the application of nanoscience and nanotechnology in medicine such as in diagnosis, imaging and therapy, surgery and drug delivery.
School: Schaefer School of Engineering & Science
Department: Chemistry, Chemical Biology & Biomedical Engineering
Program: Biomedical Engineering
Research & Education
Wang's primary research interests focus on tissue engineering, biomaterials design, signal transduction, stem cells, and nanomedicine. Ongoing research activities include multiscale design and growing hierarchical cardiovascular and musculoskeletal tissues, controllable differentiation of stem cells by understanding cellular signal transduction, as well as nanotechnology in targeting delivery and controlled release of bioactive molecules.
M.S. (Polymer Chemistry & Physics), Nankai University, China, 1995
B.S. (Chemistry), Nankai University, China, 1992
Experience & Service
Assistant Professor (08/05-present), Biomedical Engineering, Stevens Institute of Technology, Hoboken, NJ
Postdoctoral Research Fellow (08/03-07/05), Department of Dermatology, Harvard Medical School, Boston, MA
Research Fellow (08/03-07/05), Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, MA
Achievements & Professional Societies
Member, American Society of Engineering Education
Member, Tissue Engineering & Regenerative Medicine International Society (TERMIS)
Member, Society for Biomaterials
Patents & Inventions
H. Wang, “An innovative bottom-up cell assembly approach to three-dimensional tissue formation using nano- or micro-fibers”, U.S. Patent 11/985,273 (pending). S.B. Mahjour and H. Wang, “CREATION OF HAIR FOLLICLES IN TISSUE-ENGINEERED SKIN GRAFTS", U.S. Patent 13/455,649 (pending). P. Tolias, W. Lee, H. Wang, “MICROFLUIDIC-BASED CELL-CULTURING PLATFORM AND METHOD”, U.S. Patent (Pending). Woo Lee, Jenny Zilberberg, Peter Tolias, Hongjun Wang, Wenting Zhang, “AN EX VIVO HUMAN MULTIPLE MYELOMA CANCER NICHE AND ITS USE AS A MODEL FOR PERSONALIZED TREATMENT OF MULTIPLE MYELOMA”, U.S. Patent (Pending)
Xuening Chen, Xiaoling Fu, Jian-Gang Shi*, Hongjun Wang*. (2013). "Regulation of the osteogenesis of pre-osteoblasts by spatial arrangement of electrospun nanofibers in two- and three-dimensional environments", Nanomedicine: Nanotechnology, Biology, and Medicine, (in press).
Kai Wang, Meng Xu, Meifeng Zhu, Hong Su, Deling Kong, Hongjun Wang*, Lianyong Wang*. (Apr 18, 2013). "Creation of macropores in electrospun silk fibroin Scaffolds using sacrificial PEO-microparticles to improve cellular infiltration", Journal of Biomedical Materials Research, Part A, DOI: 10.1002/jbm.a.34656 .
Y. Yang, H. Wang*. (2013). "Perspectives of nanotechnology in minimally invasive therapy of breast cancer", Journal of Health Engineering, 4 (1), 67-86.
X. Chen, Y. Gu, J.-H. Lee, W. Y. Lee, H. Wang*. (2012). "Multifunctional surface with biomimetic nanofibers and drug-eluting micropatterns for infection control and bone tissue formation", eCM Journal, 24 237-248.
P.L. Leopold, J. Vincent, H. Wang. (2012). "A comparison of epithelial-to-mesenchymal transition and re-epithelialization", Seminars in Cancer Biology, 22 (5-6), 471–483.
M. K. Khaing Oo, Y. Yang, Y. Hu, M. Gome, H. Du, H. Wang*. (2012). "Gold Nanoparticle-Enhanced and Size-Dependent Generation of Reactive Oxygen Species", ACS Nano, 6 (3), 1939-47.
C. Huang, X. Fu, J. Liu, Y. Qi, S. Li*, H. Wang*. "The involvement of integrin β1 signaling in the migration and myofibroblastic differentiation of skin fibroblasts on anisotropic collagen-containing nanofibers", Biomaterials, 33 (6), 1791-1800.
J-H Lee, Y. Gu, H. Wang, W.Y. Lee. "Microfluidic 3D Bone Tissue Model for High-Throughput Evaluation of Wound-Healing and Infection-Preventing Biomaterials", Biomaterials, 33 (4), 999-1006.
X. Fu, H. Wang*. (2012). "Spatial arrangement of polycaprolactone/collagen nanofiber scaffolds regulates the wound-healing related behaviors of human adipose stromal cells", Tissue Engineering Part A, 18 (5-6), 631-42.
Y. Gu, X. Chen, J-H Lee, D.A. Monteiro, H. Wang, W.Y. Lee. (2012). "Inkjet-Printed Antibiotic- and Calcium-Eluting Bioresorbable Nanocomposite Micropatterns for Orthopaedic Implants", Acta Biomaterialia, 8 (1), 424-31.