Dr. Wang’s implementation of nanotechnology in the field of Tissue Engineering has led to dramatic improvements in this industry, and provides exciting opportunities for future health advances. His research encompasses many areas, and primarily involves the use of biomaterial scaffolds that act as a bridge upon which new cells can grow in the case of patient trauma related to skin, nerves and bone. Dr. Wang is a leading authority in Tissue Engineering, and has determined that by using nanotechnology as a means to improve upon scaffolding and develop a novel “bottom-up” approach, the healing and patient integration process would increase exponentially.
In addition to Tissue Engineering, Dr Wang also researches biomaterials design, signal transduction, stem cells, and nanomedicine. His research activities include multiscale design and growing hierarchical cardiovascular and musculoskeletal tissues, controllable differentiation of stem cells, as well as nanotechnology in targeting delivery and controlled release of bioactive molecules.
Professor Wang is a member of the American Society of Engineering Education, Tissue Engineering & Regenerative Medicine International Society (TERMIS) and the Society for Biomaterials. He is known as a pioneer of the Tissue Engineering field, has contributed to many journal articles and conference proceedings, and recently received a grant from the National Institute of Health (NIH) for his work involving development of skin grafts that promote rapid re-growth due to improved scaffolding on the bone tissue engineering frontier.
Xuening Chen, Xiaoling Fu, Jian-Gang Shi*, Hongjun Wang*. (2013). Regulation of the osteogenesis of pre-osteoblasts by spatial arrangement of electrospun nanofibers in two- and three-dimensional environments, Nanomedicine: Nanotechnology, Biology, and Medicine, (in press)
Y. Yang, H. Wang*. (2013). Perspectives of nanotechnology in minimally invasive therapy of breast cancer, Journal of Health Engineering, 4 (1), 67-86
Kai Wang, Meng Xu, Meifeng Zhu, Hong Su, Deling Kong, Hongjun Wang*, Lianyong Wang*. (Apr 18, 2013). Creation of macropores in electrospun silk fibroin Scaffolds using sacrificial PEO-microparticles to improve cellular infiltration, Journal of Biomedical Materials Research, Part A, DOI: 10.1002/jbm.a.34656
Y. Gu, X. Chen, J-H Lee, D.A. Monteiro, H. Wang, W.Y. Lee. ( 2012). Inkjet-Printed Antibiotic- and Calcium-Eluting Bioresorbable Nanocomposite Micropatterns for Orthopaedic Implants, Acta Biomaterialia, 8 (1), 424-31
X. Fu, H. Wang*. ( 2012). Spatial arrangement of polycaprolactone/collagen nanofiber scaffolds regulates the wound-healing related behaviors of human adipose stromal cells, Tissue Engineering Part A, 18 (5-6), 631-42
M. K. Khaing Oo, Y. Yang, Y. Hu, M. Gome, H. Du, H. Wang*. ( 2012). Gold Nanoparticle-Enhanced and Size-Dependent Generation of Reactive Oxygen Species, ACS Nano, 6 (3), 1939-47
P.L. Leopold, J. Vincent, H. Wang. ( 2012). A comparison of epithelial-to-mesenchymal transition and re-epithelialization, Seminars in Cancer Biology, 22 (5-6), 471–483
X. Chen, Y. Gu, J.-H. Lee, W. Y. Lee, H. Wang*. ( 2012). Multifunctional surface with biomimetic nanofibers and drug-eluting micropatterns for infection control and bone tissue formation, eCM Journal, 24 237-248
J-H Lee, Y. Gu, H. Wang, W.Y. Lee. Microfluidic 3D Bone Tissue Model for High-Throughput Evaluation of Wound-Healing and Infection-Preventing Biomaterials, Biomaterials, 33 (4), 999-1006
C. Huang, X. Fu, J. Liu, Y. Qi, S. Li*, H. Wang*. The involvement of integrin β1 signaling in the migration and myofibroblastic differentiation of skin fibroblasts on anisotropic collagen-containing nanofibers, Biomaterials, 33 (6), 1791-1800