Biological principles and their physical and chemical aspects are explored at the cellular and molecular level. Major emphasis is placed on cell structure, the processes of energy conversion by plant and animal cells, genetics and evolution, and applications to biotechnology.
An introductory laboratory illustrating basic techniques and principles of modern biology by means of laboratory experiments and simulated experiments. This laboratory does not satisfy medical school admission requirements.
The structure and function of the cell and its subcellular organelles is studied. Biological macromolecules, enzymes, biomembranes, biological transport, bioenergetics, DNA replication, protein synthesis and secretion, motility, and cancer are covered. Cell biology experiments and interactive computer simulation exercises are conducted in the laboratory.
Physiochemical principles underlying the coordinated function in multicellular organisms are studied. Electrical properties of biological membranes, characteristics of tissues, nerve-muscle electrophysiology, circulatory, respiratory, endocrine, digestive, and excretory systems are covered. Computer simulation experiments and data acquisition methods to evaluate and monitor human physiological systems are conducted in the laboratory.
Introduction to the study of molecular basis of inheritance. Starts with classical Mendelian genetics and proceeds to the study and function of DNA, gene expression and regulation in prokaryotes and eukaryotes, genome dynamics and the role of genes in development, and cancer. All topics include discussions of current research advances. Accompanied by laboratory section that explores the lecture topics in standard wet laboratory experiments and in computer simulations.
Fundamentals of control processes governing physiological systems analyzed at the cellular and molecular level. Biological signal transduction and negative feedback control of metabolic processes. Examples from sensory, nervous, cardiovascular, and endocrine systems. Deviations that give rise to abnormal states; their detection, and the theory behind the imaging and diagnostic techniques such as MRI, PET, SPECT; and the design and development of therapeutic drugs. The principles, uses, and applications of biomaterials and tissue engineering techniques; and problems associated with biocompatibility. Students (or groups of students) are expected to write and present a term project.
This laboratory course introduces essential techniques in molecular biology and genetic engineering in a project format. The course includes aseptic technique and the handling of microbes; isolation and purification of nucleic acids; construction, selection and analysis of recombinant DNA molecules; restriction mapping; immobilization and hybridization of nucleic acids; and labeling methods of nucleic acid probes.
The cells and molecules of the immune system and their interaction and regulation; the cellular and genetic components of the immune response, the biochemistry of antigens and antibodies, the generation of antibody diversity, cytokines, hypersensitivities, and immunodeficiencies (i.e. AIDS); and transplants and tumors. Use of antibodies in currently emerging immunodiagnostic techniques such as ELISA, disposable kits, molecular targets, and development of vaccines utilizing molecular biological techniques, such as recombinant and subunit vaccines. Students (or groups of students) are expected to write and present a term project.
Topics of timely interest will be treated in an interdisciplinary fashion; recent developments will be surveyed in fields such as biosynthesis, radioactive and stable isotope techniques, genesis of life chemicals, nucleic acids and replication, genetic defects, and metabolic errors.
Participation in a small group project, under the guidance of a faculty member, whose prior approval is required. Experimentation, application of chemical knowledge and developmental research leading to the implementation of a working chemical process. Individual or group written report required.
Topics of current interest in biochemical research are discussed, such as: enzyme chemistry, biochemical genetics and development, cellular control mechanism, biochemistry of cell membranes, bioenergetics, and microbiology.
Schaefer School of Engineering & Science
Chemistry, Chemical Biology & Biomedical Engineering
Chemistry & Chemical Biology
Research & Education
Post-Doctoral Research: Columbia University, New York, NY, College of Physicians and Surgeons, Neurophysiology and Cellular Biophysics
Ph.D., M.Phil., M.A., Physiology, College of Physicians and Surgeons, Columbia University, New York, NY
M.S., Chemical Engineering, Columbia University, New York, NY
B.S., Chemistry, Robert College, Istanbul
Developing and applying chemical methods to study biological problems in the areas of proteomics and microarray technologies
Neuromuscular physiology, biochemistry and biophysics of muscle contraction, synaptic transmission, immunochemical mechanisms
Experience & Service
Dr. Kumbaraci is the advisor for the Accelerated Chemical Biology Program, Chemical Biology Program, and an advisor for the Graduate Chemical Biology Program. She has been on the Stevens Faculty since 1979.
APS -- American Physiological Society
SFN -- Society for Neuroscience
National Association of Advisors for the Health Professions
Sigma Xi -- Honorary Research Society
Phi Lambda Epsilon -- Honorary Chemistry Society
AED -- National Honorary Premedical Society
Stevens Institute of Technology, Associate Professor, 1979-present
Barnard/Columbia College and NYU, Organic Chemistry, Biology Instructor
Artificial Organs Research Laboratory, Columbia University, New York, NY
Lever Brothers Headquarters, New York, NY, Pharmaceutical Marketing
Siemens und Halske, Germany, Electrodeposition Laboratory
Eczacibasi Pharmaceutical Co., Analytical Research and Product Development Chemist *Patents on Aerosol and Liquid Pharmaceutical Products
Achievements & Professional Societies
Honors & Awards
ESSO Academic Scholarship
Grants, Contracts & Funds
NSF-1979-1985: Honors Courses and Workshops for Pre-College Teachers of Science in Modern Biology
Nuran M. Kumbaraci. (2008). Chemical Biology Laboratory, Wiley.
N. M. Kumbaraci, W. L. Nastuk. "Action of Caffeine in Excitation-Contraction Coupling of Frog Skeletal Muscle Fibres", The Journal of Physiology, 325 (1), 195-211.
N. M. Kumbaraci, W.L. Nastuk. "Effects of Δ9-Tetrahydrocannabinol on Excitable Membranes and Neuromuscular Transmission", Molecular Pharmacology, 17, 344-349.